sos1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60029	SOS1-IN-11		Raf
	SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).		Raf
T73164	SOS1-IN-15		Raf
	SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.		Raf
T12978	NSC-70220	SOS1-IN-1	Raf
	SOS1-IN-1 is an inhibitor of SOS1.		Raf
T63118	SOS1-IN-8
	SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).
T62712	SOS1-IN-10
	SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM).
T61963	SOS1-IN-3
	SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.
T79183	SOS1-IN-16		Ras
	SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of 8.9μM when testosterone is employed as a substrate. This co...		Ras
T63044	SOS1-IN-6
	SOS1-IN-6 (compound 33-P1) is a potent inhibitor of SOS1, acting on SOS1-G12D (IC50: 14.9 nM) and SOS1-G12V (IC50: 73.3 nM).
T62003	SOS1-IN-13
	SOS1-IN-13 is a potent inhibitor of son of sevenless homolog 1 (SOS1). SOS1-IN-13 shows IC 50 s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 has research value in anticancer.
T63083	SOS1-IN-4
	SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.
T63781	SOS1-IN-5
	SOS1-IN-5 is a pyrimidine bicyclic derivative and a potent inhibitor of SOS1. SOS1-IN-5 interferes with the RAS-SOS1 interaction, thereby blocking KRAS activation and exhibiting broad-spectrum inhibition of KRAS activity...
T62923	SOS1-IN-7
	SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).
T62478	SOS1-IN-9
	SOS1-IN-9 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 116.5 nM).
T62371	SOS1-IN-12
	SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).
T63887	SOS1-IN-14
	SOS1-IN-14 is a selective, potent, orally active SOS1 inhibitor (IC50: 3.9 nM). sOS1-IN-14 is absorbed in the intestine using a P-glycoprotein-mediated efflux mechanism. sOS1-IN-14 can be used in the study of KRAS mutate...
T63201	SOS1 activator 1
	SOS1 activator 1 is an activator of SOS1-mediated nucleotide exchange (Kd: 44 nM).SOS1 is a guanine nucleotide exchange factor that binds to Ras proteins and catalyzes the exchange of GDP for GTP on RAS, resulting in the...
T79162	SOS1/KRAS-IN-1		Ras
	SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].		Ras
T79098	PROTAC SOS1 degrader-4		PROTACs
	PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].		PROTACs
T75020	PROTAC SOS1 degrader-3
	PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].
T74356	PROTAC SOS1 degrader-2
	PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
T74439	PROTAC SOS1 degrader-1
	PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations a...
T12979	BI-3406		p38 MAPK , MAPK , Ras
	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.		p38 MAPK , MAPK , Ras
TP2116	SAH-SOS1A
	KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a conc...
T76059	SAH-SOS1A TFA
	SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di...
T5418	BAY-293		Raf , Ras
	BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).		Raf , Ras
T38170	RMC-0331	RM-023	Raf
	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.		Raf
T8721L	I-37 free base( 2359690-13-2(free base))		Raf
	I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.		Raf
T9755	MRTX0902	UNII-CRG69FR93G	Raf
	MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.		Raf
T69529	BI-0474		Ras
	BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G...		Ras
T8746L	I-49 free base	Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-,I-49	Raf
	I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibito...		Raf
T24554	NSC-658497	NSC658497
	NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.
T72347	KRAS G12C inhibitor 24
	KRAS G12C Inhibitor 24 is a potent inhibitor that effectively disrupts the interaction between KRAS G12C and SOS1, achieving an inhibitory concentration (IC 50) of less than 50 nM.
T71348	UC-773587
	UC-773587 is a novel inhibitor of Ras signaling, binding to the Ras switch II interaction region of SOS1.
T72356	KRAS G12C inhibitor 56
	KRAS G12C inhibitor 56, a powerful inhibitor of SOS1 with an inhibitory concentration (IC50) of 1.6 nM, holds promise for use in cancer research.
T37422	Ras Inhibitory Peptide
	Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to t...
T8721	I-37	Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-	Raf
	I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.		Raf
T63927	KRAS G12C inhibitor 25
	KRAS G12C inhibitor 25 is an inhibitor of KRAS G12C. KRAS G12C inhibitor 25 inhibits the SOS1-assisted GDP/GTP exchange activity of KRAS-G12C mutants with an IC50 value of 0.48 nM.
T69195	UC-857993
	UC-857993, a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), effectively suppresses catalytic activity. In addition to inhibiting ERK and Ras activation, it also hampers the growth of mouse embryonic fibroblasts...

Compounds

SOS1-IN-11

T60029

PROTAC SOS1 degrader-4

T79098

Synonym:

Target: PROTACs

PROTAC SOS1 degrader-3

T75020

Synonym:

Target:

PROTAC SOS1 degrader-2

T74356

Synonym:

Target:

PROTAC SOS1 degrader-1

Target: p38 MAPK, MAPK, Ras

I-37 free base( 2359690-13-2(free base))

Synonym: UNII-CRG69FR93G

Synonym: Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-,I-49

KRAS G12C inhibitor 24

KRAS G12C inhibitor 56

T72356

Synonym:

Target:

Ras Inhibitory Peptide

Synonym: Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-

Target: Raf

KRAS G12C inhibitor 25

Cat No.	Product Name	Species	Expression System
TMPU-00002	SOS1-Cat Protein, Human, Recombinant (His)	Human	E. coli
	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM...

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Targets

Compounds

Recombinant Proteins

Compounds

Recombinant Proteins