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MAPK Raf BAY-293

BAY-293

Catalog No. T5418   CAS 2244904-70-7

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).

BAY-293, CAS 2244904-70-7
Pack Size Availability Price/USD Quantity
1 mg In Stock 70.00
5 mg In Stock 212.00
10 mg In Stock 378.00
25 mg In Stock 832.00
50 mg In stock 1499.00
100 mg In stock 2705.00
1 mL * 10 mM (in DMSO) In stock 232.00
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Purity 96.80%
Biological Description
Chemical Properties
Storage & Solubility Information
Description BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
Targets&IC50 KRAS-SOS1 interaction
In vitro BAY-293 is a SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM and displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20 uM). It inhibits the activation of RAS in HeLa cells with IC50 of 410 nM, efficiently inhibits pERK levels in K562 cells after incubation for 60 min without affecting total protein levels of ERK (IC50: 180 nM). BAY-293 shows antiproliferative activity against wild-type KRAS cell lines (K562, MOLM-13; IC50~1 uM) and cell lines with KRASG12C mutation (NCI-H358, Calu-; IC50~3 uM) by preventing the formation of the KRAS-SOS1 complex.
Molecular Weight 448.58
Formula C25H28N4O2S
CAS No. 2244904-70-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 110 mg/mL (245.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Apoptosis Compound Library MAPK Inhibitor Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Metabolism Compound Library Anti-obesity Compound Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library Glutamine Metabolism Compound Library

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