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Search Results for " smad1 "

Targets

3

Compounds

2

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1943 ML347 LDN 193719 ALK , TGF-beta/Smad
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T16904 Smurf1-IN-A01 A01 Others
Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.
T76863 Elezanumab AE12-1Y-QL,ABT-555 TGF-beta/Smad
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab pro...
Cat No. Product Name Synonyms Targets
T3924 Astragaloside II Astrasieversianin VIII TGF-beta/Smad
Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, ...
TN3753 Dalbergioidin Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01129 SMAD1 Protein, Human, Recombinant (GST) Human E. coli
SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcripti...
TMPH-01702 SMAD6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01269 SMURF2 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPH-01414 GDF2 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. GDF2 Protein, H...
TMPJ-01108 SMAD4 Protein, Human, Recombinant (His) Human E. coli
SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric...
TMPJ-00966 GDF-5 Protein, Human, Recombinant Human E. coli
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor...
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