sirt2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12920	Sirt2-IN-1		Sirtuin
	Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).		Sirtuin
T62515	SIRT2-IN-9		Sirtuin
	SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used for cancer research.		Sirtuin
T16667	PROTAC Sirt2 Degrader-1		Sirtuin
	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Si...		Sirtuin
T63712	Sirt2-IN-5
	Sirt2-IN-5 is a potent inhibitor of SIRT2.
T74937	Sirt2-IN-7
	Sirt2-IN-7 (compound 22) is a selective SIRT2 inhibitor with an IC50 of 178.2 nM and a Ki of 154.3 nM, utilized in cancer research [1].
T63102	SIRT2-IN-10
	SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.
T63417	Sirt2-IN-6
	Sirt2-IN-6 is a potent and selective inhibitor of SIRT2 (IC50: 0.815 μM) and can be used to study cancer.
T73000	SIRT2-IN-11
	SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2, demonstrating an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner and activates the expression of CDKN1A, PUMA, and NOXA, wh...
T18641	SirReal1-O-propargyl	PROTAC Sirt2-binding moiety 1	Others
	SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates by binding to the cereblon ligand through a linker, facilita...		Others
T82167	HSP70/SIRT2-IN-2		HSP
	HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].		HSP
T82168	HSP70/SIRT2-IN-1		Sirtuin
	HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1].		Sirtuin
T9998	MIND4-19		Sirtuin
	MIND4-19 is an inhibitor of SIRT2 with antitumor activity.		Sirtuin
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T6371	AGK2		Apoptosis , Sirtuin
	AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.		Apoptosis , Sirtuin
T6984	SirReal2		Sirtuin
	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.		Sirtuin
T5490	AK-7		Sirtuin
	AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.		Sirtuin
TN7093	N-Caffeoyltryptophan	trans-Caffeoyl-L-tryptophan	Sirtuin
	N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).		Sirtuin
T5096	SRT 1720		Sirtuin , Autophagy
	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.		Sirtuin , Autophagy
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T5124	SRT 1720 dihydrochloride[925434-55-5(free base)]		Sirtuin
	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).		Sirtuin