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N-Caffeoyltryptophan

Catalog No. TN7093 CAS 109163-69-1

Synonyms: trans-Caffeoyl-L-tryptophan

N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

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N-Caffeoyltryptophan, CAS 109163-69-1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
Targets&IC50	SIRT1:34μM, Sirt2:8.7 μM
In vitro	In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1].

Synonyms	trans-Caffeoyl-L-tryptophan
Molecular Weight	366.37
Formula	C20H18N2O5
CAS No.	109163-69-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (122.83 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Park JB. Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor. PLoS One. 2016 Mar 17;11(3):e0150392.

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Keywords

N-Caffeoyltryptophan 109163-69-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin trans-Caffeoyl-L-tryptophan N Caffeoyltryptophan NCaffeoyltryptophan Inhibitor inhibitor inhibit

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