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N-Caffeoyltryptophan
🥰Excellent
Catalog No. TN7093Cas No. 109163-69-1
Alias trans-Caffeoyl-L-tryptophan
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
N-Caffeoyltryptophan
🥰Excellent
Purity: 99.50%
Catalog No. TN7093Alias trans-Caffeoyl-L-tryptophanCas No. 109163-69-1
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $106 | In Stock | |
| 2 mg | $148 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $355 | In Stock | |
| 25 mg | $588 | In Stock | |
| 50 mg | $838 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $259 | In Stock |
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Purity:99.50%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
| Targets&IC50 | SIRT1:34μM, SIRT2:8.7 μM |
| In vitro | In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1]. |
| Alias | trans-Caffeoyl-L-tryptophan |
| Molecular Weight | 366.37 |
| Formula | C20H18N2O5 |
| Cas No. | 109163-69-1 |
| Smiles | C([C@H](NC(/C=C/C1=CC(O)=C(O)C=C1)=O)C(O)=O)C=2C=3C(NC2)=CC=CC3 |
| Relative Density. | 1.460 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (122.83 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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