Powder: -20°C for 3 years
In solvent: -80°C for 2 years
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
Description | N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
Targets&IC50 | SIRT1:34μM, Sirt2:8.7 μM |
In vitro | In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1]. |
Synonyms | trans-Caffeoyl-L-tryptophan |
Molecular Weight | 366.37 |
Formula | C20H18N2O5 |
CAS No. | 109163-69-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 45 mg/mL (122.83 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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N-Caffeoyltryptophan 109163-69-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin trans-Caffeoyl-L-tryptophan N Caffeoyltryptophan NCaffeoyltryptophan Inhibitor inhibitor inhibit