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N-Caffeoyltryptophan

Name: N-Caffeoyltryptophan
Brand: TargetMol
SKU: TN7093
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7093Cas No. 109163-69-1

Alias trans-Caffeoyl-L-tryptophan

N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

N-Caffeoyltryptophan

🥰Excellent

Purity: 99.5%

Catalog No. TN7093Alias trans-Caffeoyl-L-tryptophanCas No. 109163-69-1

N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

Pack Size	Price	Availability
1 mg	$106	In Stock
2 mg	$148	In Stock
5 mg	$239	In Stock
10 mg	$355	In Stock
25 mg	$588	In Stock
50 mg	$838	In Stock
1 mL x 10 mM (in DMSO)	$259	In Stock

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Purity:99.5%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
Targets&IC50	SIRT2:8.7 μM, SIRT1:34μM
In vitro	In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1].
Synonyms	trans-Caffeoyl-L-tryptophan

Chemical Properties

Molecular Weight	366.37
Formula	C₂₀H₁₈N₂O₅
Cas No.	109163-69-1
Smiles	C([C@H](NC(/C=C/C1=CC(O)=C(O)C=C1)=O)C(O)=O)C=2C=3C(NC2)=CC=CC3
Relative Density.	1.460 g/cm3 (Predicted)
Sequence	coumaroyl(3-OH)-Trp
Sequence Short	W

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (122.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7295 mL	13.6474 mL	27.2948 mL	136.4741 mL
5 mM	0.5459 mL	2.7295 mL	5.4590 mL	27.2948 mL
10 mM	0.2729 mL	1.3647 mL	2.7295 mL	13.6474 mL
20 mM	0.1365 mL	0.6824 mL	1.3647 mL	6.8237 mL
50 mM	0.0546 mL	0.2729 mL	0.5459 mL	2.7295 mL
100 mM	0.0273 mL	0.1365 mL	0.2729 mL	1.3647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc