Search Result

Search Results for " shh "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1810	Purmorphamine	Shh Signaling Antagonist VI	Hedgehog/Smoothened , Smo , Autophagy
	Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.		Hedgehog/Smoothened , Smo , Autophagy
T9532	MRT-81		Others
	MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...		Others
TP1663L	CysHHC10 acetate	CysHHC10 acetate(1408311-03-4 free base)	Antibacterial
	CysHHC10 acetate shows antibacterial activities against both Gram-positive and Gram-negative bacteria with MIC of 10.1, 20.2, 2.5, and 1.3 mM for E. coli, P. aeruginosa, S. aureus, and S. epidermidis, respectively.		Antibacterial
T76036	CysHHC10 TFA
	CysHHC10 TFA, a synthetic antimicrobial peptide (AMP), demonstrates potent effectiveness against a broad spectrum of bacteria, including both Gram-positive and Gram-negative strains. Specifically, Minimum Inhibitory Conc...
TP1663	CysHHC10
	CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.
TP1691	CysHHC10 TFA(1408311-03-4 free base)	CysHHC10 TFA
	CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.
T22089	HPI 1		Hedgehog/Smoothened
	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a...		Hedgehog/Smoothened
T16287	Neurodazine		DNA Methyltransferase
	Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt and Shh signaling.		DNA Methyltransferase
T13004	SSTC3		Casein Kinase , Wnt/beta-catenin
	SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd ...		Casein Kinase , Wnt/beta-catenin
T2450	SANT-1	SANT 1	Hedgehog/Smoothened , Smo
	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).		Hedgehog/Smoothened , Smo
T69189	SANT-2
	SANT-2 is a potent inhibitor of Shh signaling pathway.
T26110	Robotnikinin
	Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.
T26899	BRD50837	BRD-50837,BRD 50837
	BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T26901	BRD-9526	BRD 9526
	BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T61895	AZD7254
	AZD7254 is an oral effective Smoothened (SMO) inhibitor, and the EC50 of sonic Hh protein (shh) is 1.0 nM.
T61897	SMO-IN-1
	SMO-IN-1 (Compound 15) is an oral effective Smoothened (SMO) inhibitor. The EC50 value of sonic Hh protein (shh) is 89 nM.
T12797	RU-SKI 43	RUSKI 43	Hedgehog/Smoothened , Acyltransferase
	RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compound for the treatment of lung adenocarcinomas.RU-SKI 43 reduc...		Hedgehog/Smoothened , Acyltransferase
T62388	RUSKI-201 dihydrochloride
	RUSKI-201 dihydrochloride is a potent and specific inhibitor of Hedgehog acyltransferase (Hhat) (IC50: 0.20 μM). RUSKI-201 dihydrochloride blocks Hh signalling in Shh overexpressing cells and has an inhibitory effect on ...
T35541	Lipoxygenin
	Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-de...
T35558	KAAD-Cyclopamine
	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...

Compounds

Purmorphamine

T1810

Synonym: Shh Signaling Antagonist VI

Target: Hedgehog/Smoothened, Smo, Autophagy

Synonym: CysHHC10 acetate(1408311-03-4 free base)

Target: Antibacterial

CysHHC10 TFA(1408311-03-4 free base)

TP1691

Synonym: CysHHC10 TFA

Target: Hedgehog/Smoothened

Neurodazine

T16287

Synonym:

Target: DNA Methyltransferase

SSTC3

T13004

Synonym:

Target: Casein Kinase, Wnt/beta-catenin

SANT-1

T2450

Synonym: SANT 1

Target: Hedgehog/Smoothened, Smo

Synonym: BRD-50837,BRD 50837

Target: Hedgehog/Smoothened, Acyltransferase

RUSKI-201 dihydrochloride

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01170	SHH Protein, Mouse, Recombinant	Mouse	E. coli
	SHH Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q62226.
TMPJ-01127	SHH Protein, Human, Recombinant	Human	E. coli
	SHH Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19 KDa and the accession number is Q15465.
TMPJ-01128	SHH Protein, Human, Recombinant (C24II)	Human	E. coli
	SHH Protein, Human, Recombinant (C24II) is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q15465.
TMPJ-01171	SHH Protein, Mouse, Recombinant (C25II)	Mouse	E. coli
	SHH Protein, Mouse, Recombinant (C25II) is expressed in E. coli expression system. The predicted molecular weight is 18-20 KDa and the accession number is Q62226.
TMPY-02832	SHH Protein, Human, Recombinant (aa 198-462, His)	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 198-462, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is Q15465.
TMPY-02905	SHH Protein, Human, Recombinant (aa 1-197, His)	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 1-197, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is Q15465.
TMPH-02321	GLI1 Protein, Human, Recombinant (His)	Human	E. coli
	Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital deve...
TMPJ-00716	Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His)	Human	HEK293 Cells
	Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to D...
TMPY-02384	MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)	Human	E. coli
	MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expr...
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific respo...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti...