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SSTC3

Catalog No. T13004 CAS 1242422-09-8

SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd of 32 nM.

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SSTC3, CAS 1242422-09-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 247.00
25 mg	6-8 weeks	$ 766.00
50 mg	6-8 weeks	$ 996.00
100 mg	6-8 weeks	$ 1,490.00
1 mL * 10 mM (in DMSO)	In stock	$ 324.00

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Purity: 98.65%

Biological Description

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Storage & Solubility Information

Description	SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.SSTC3 is a potent HIF1α inhibitor with a Kd of 32 nM.
In vitro	In colorectal cancer (CRC) cell lines, the results of SSTC3 (0-1 μM; 5 days) indicate that SSTC3 decreased cell viability[1].
In vivo	In five-week-old Apcmin mice, SSTC3 (10 mg/kg; intraperitoneal injection, for 1 month) inhibited the growth of tumors driven by Apc mutation[1].

Molecular Weight	518.53
Formula	C23H17F3N4O3S2
CAS No.	1242422-09-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

References and Literature

1. Li B, et al, Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.

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Keywords

SSTC3 1242422-09-8 Cytoskeletal Signaling Metabolism Stem Cells Casein Kinase Wnt/beta-catenin SSTC-3 SSTC 3 inhibitor inhibit

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