sh2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T82261	Grb2 SH2 domain inhibitor 1
	Grb2 SH2 Domain Inhibitor 1 is a cyclic cell-penetrating peptide (CPP) featuring a conformationally restricted d-pro-l-pro motif ring (AF Φ Rpprrfq), where Φ represents L-naphthylalanine, R denotes D-arginine, and P indi...
T77994	Grb2 SH2 domain inhibitor 1 TFA
	Grb2 SH2 Domain Inhibitor 1 TFA is a cyclic cell-penetrating peptide (CPP) featuring a conformationally restricted d-pro-l-pro motif ring (AF Φ Rpprrfq), where Φ represents L-naphthylalanine, R signifies D-arginine, and ...
T9339	Stafia-1		STAT
	Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.		STAT
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T9723	GluR6 antagonist-1		Src
	GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.		Src
T10877	CPDA		Phosphatase
	CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).		Phosphatase
T4216	STAT5-IN-1	STAT5 Inhibitor	STAT
	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.		STAT
T14037	3α-Aminocholestane	5α-Cholestan-3α-amine	Phosphatase
	3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases.		Phosphatase
TQ0003L1	740 Y-P acetate	PDGFR 740Y-P Acetate,740YPDGFR acetate,740 Y-P acetate(1236188-16-1 Free base)	PI3K
	740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.		PI3K
T14327	AS1949490		Phosphatase
	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.		Phosphatase
T62491	STAT3-IN-13		STAT
	STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which in...		STAT
TQ0003	740 Y-P	740YPDGFR,PDGFR 740Y-P	PI3K , Autophagy
	740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.		PI3K , Autophagy
T27707	K118	K 118,K-118
	K118 is an inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). It reverses diet- and age-associated obesity and metabolic syndrome.
T30089	AP-22161	AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161
	AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast ...
T23751	AQX-MN115
	AQX-MN115 is an SH2- containing inositol 5- phosphatase modulator.
T38965	EPQpYEEIPIYL
	EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains.
T40219	CGP78850
	CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist that holds potential for cancer research.
T12905	SI-109		STAT
	SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.		STAT
TP2085	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
	Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
T24838	Stafib-1	Stafib 1,Stafib1	STAT
	Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.		STAT