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3α-Aminocholestane
🥰Excellent
Catalog No. T14037Cas No. 2206-20-4
Alias 5α-Cholestan-3α-amine
3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases.
3α-Aminocholestane
🥰Excellent
Catalog No. T14037Alias 5α-Cholestan-3α-amineCas No. 2206-20-4
3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $49 | In Stock |
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Purity:≥98.0%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases. |
| Targets&IC50 | SHIP1:2.5 μM |
| In vitro | MM cells were treated with increasing concentrations of 3α-Aminocholestane (3AC) for 48 hours. After cell lysis, proteins were separated by SDS-PAGE and probed with antibodies against SHIP1, SHIP2, and PTEN. The results indicate that treatment with3α-Aminocholestane (3AC)leads to proteasomal degradation of the SHIP1 protein[1]. |
| In vivo | NOD/SCID/γcIL2R (NSG) mutant mice were inoculated with 1 × 10^7 MM cells (OPM2) via intraperitoneal injection. Six hours later, the mice received the first injection of 3α-Aminocholestane (3AC), followed by daily injections for the next 7 days, and subsequently, injections every two weeks for the following 15 weeks. The results indicate that treatment with 3α-Aminocholestane (3AC) inhibits the growth of MM cells in vivo.[1]. |
| Alias | 5α-Cholestan-3α-amine |
| Molecular Weight | 387.68 |
| Formula | C27H49N |
| Cas No. | 2206-20-4 |
| Smiles | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](N)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C |
| Relative Density. | 0.930 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: <0.1 mg/mL Ethanol: 30 mg/mL (77.38 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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