12
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36105 | Coumarin-SAHA | coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA | |
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanili... | |||
T35765 | SAHA-BPyne | ||
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA deriva... | |||
T21749 | 4-iodo-SAHA | ||
4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 μM for Skbr3, HT29, U937, JA16, and HL60 cell lines, resp... | |||
T71011 | Perfluorinated SAHA | ||
Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-... | |||
T1583 | Vorinostat | MK0683,suberoylanilide hydroxamic acid,SAHA | Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy |
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i... | |||
T19556 | SAHA chloroalkane T1 | Others | |
SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting ... | |||
T73454 | SAHA-OH | HDAC | |
SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1... | |||
T3199 | PTACH | NCH-51,Cpd 51 | HIV Protease , HDAC |
PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM). | |||
TN4933 | Sahandol | Antifection | |
Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. | |||
T36874 | 7-Bromoheptanoic Acid | ||
7-Bromoheptanoic acid is a building block.1,2It has been used in the synthesis of azide-based nicotinamide phosphoribosyltransferase (Nampt) inhibitors with anticancer activity and SAHA derivatives that inhibit histone d... | |||
T70779 | BPR1J-340 | ||
BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular prol... | |||
T70962 | MHY219 | ||
MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) whe... |