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PTACH

Catalog No. T3199 CAS 848354-66-5

Synonyms: NCH-51, Cpd 51

PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).

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PTACH, CAS 848354-66-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
2 mg	In stock	$ 113.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 348.00
25 mg	In stock	$ 557.00
50 mg	In stock	$ 783.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 227.00

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Purity: 99.74%

Purity: 98.59%

Purity: 87.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
Targets&IC50	HDAC:1-10 μM (EC50)
Kinase Assay	mTOR and PI3K Cellular Assays: Cellular IC50 values for mTOR are determined using p53?/? MEFs. Cells are treated with vehicle or increasing concentrations of Torin 2 for 1 h and then lyse. Phosphorylation of S6K1 Thr-389 is monitored by immunoblotting using a phospho-specific antibody. Meanwhile, cellular IC50 values for PI3Ka are determined based on phosphorylation of Akt Thr-308 in p53?/?/mLST8?/? MEFs or human PC3 cells expressing the S473D mutant of Akt1.

Synonyms	NCH-51, Cpd 51
Molecular Weight	390.56
Formula	C20H26N2O2S2
CAS No.	848354-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (140.82 mM)

References and Literature

1. Suzuki T, et al. J Med Chem. 2005 Feb 24;48(4):1019-32.

Citations

1. Liu H, Zhang Q, He X, et al.Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.Nature Communications.2023, 14(1): 3271.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Cancer Cell Differentiation Compound Library Histone Modification Compound Library Epigenetics Compound Library Anti-Aging Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PTACH 848354-66-5 Chromatin/Epigenetic DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HIV Protease HDAC HIV-1 inhibit NCH-51 Cpd 51 HIV Inhibitor Histone deacetylases hyperacetylation NCH51 Anti-cancer p21WAF1/CIP1 Human immunodeficiency virus SAHA NCH 51 inhibitor

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