rarβ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1093	Adapalene	CD271	Apoptosis , Retinoid Receptor , Autophagy
	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.		Apoptosis , Retinoid Receptor , Autophagy
T21714	BMS453	BMS 453,BMS-189453	Retinoid Receptor
	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.		Retinoid Receptor
T22920	LE135	LE 135	Retinoid Receptor
	LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent ...		Retinoid Receptor
T26854	BMS641	BMS-641,BMS-209641,BMS 641	Retinoid Receptor
	BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular maturation into specialized neuronal subtypes.		Retinoid Receptor
T14911	CD2665		Retinoid Receptor
	CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.		Retinoid Receptor
T7586	Trifarotene	CD5789	Retinoid Receptor , Autophagy
	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).		Retinoid Receptor , Autophagy
TQ0097	AGN 193109		Retinoid Receptor , Autophagy
	AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).		Retinoid Receptor , Autophagy
T10261	AGN 196996		Others , Retinoid Receptor , Autophagy
	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectively.		Others , Retinoid Receptor , Autophagy
T1288	TTNPB	AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410	Apoptosis , Retinoid Receptor , Autophagy
	TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively.		Apoptosis , Retinoid Receptor , Autophagy
T61588	AGN 192870		Apoptosis , Retinoid Receptor
	AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.		Apoptosis , Retinoid Receptor
T14143	AGN 194310	VTP-194310	Retinoid Receptor
	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].		Retinoid Receptor
T71442	CD564
	CD564 is a novel selective inhibitor of RARβ/γ.
T10263	AGN 205728		Others
	AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ.		Others
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T22196	CD 2314
	CD2314 is a potent and subtype-selective RARβ receptor agonist with a Kd of 195 nM in S91 melanoma cells [1].
T1051	Retinoic acid	Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy
	Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat...
T14144	AGN-195183		Others
	AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compoun...		Others
T23005	MM 11253	MM-11253	Retinoid Receptor
	MM 11253 is a RARγ antagonist with IC50 of 44nM.		Retinoid Receptor
T28589	Ro 41-5253	Ro-41-5253,Ro 415253	Apoptosis , Retinoid Receptor
	Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation and induces apoptosis in MCF-7 and...		Apoptosis , Retinoid Receptor
T10246	Adapalene sodium salt	CD 271 sodium salt	Others
	Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.		Others