Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 596.00 | |
25 mg | 8-10 weeks | $ 1,710.00 | |
50 mg | 8-10 weeks | $ 2,230.00 | |
100 mg | 8-10 weeks | $ 3,390.00 |
Description | AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2]. |
Targets&IC50 | RARβ:2 nM (kd), RARγ:5 nM (kd), RARα:3 nM (kd) |
In vitro | AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells[2]. AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB[2]. AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis[2]. |
In vivo | AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310[3]. |
Synonyms | VTP-194310 |
Molecular Weight | 424.55 |
Formula | C28H24O2S |
CAS No. | 229961-45-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (117.77 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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AGN 194310 229961-45-9 Metabolism Retinoid Receptor VTP-194310 AGN-194310 AGN194310 VTP 194310 VTP194310 inhibitor inhibit