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CD2665

Catalog No. T14911 CAS 170355-78-9

CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.

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CD2665, CAS 170355-78-9

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1 mg	In stock	$ 83.00
5 mg	In stock	$ 167.00
10 mg	In stock	$ 253.00
25 mg	In stock	$ 425.00

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Purity: 99.67%

Biological Description

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Description	CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
Targets&IC50	RARβ:306 nM(ki), RARγ:（ki）110 nM
In vitro	In 3T3 cells, CD2665 (100 nM) abrogates the antiproliferative effects of ATRA, CD271 (adapalene, a RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level[1].
In vivo	In mice submitted to 10 months of ethanol consumption, CD2665 (0.6 mg/kg; s.c.) decreases brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels[2].

Molecular Weight	486.6
Formula	C31H34O5
CAS No.	170355-78-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 22.5mg/mL (46.2mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim MJ, et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J Invest Dermatol. 2000 Feb;114(2):349-53. 2. Koyama E, et al.Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice. J Bone Miner Res. 2021 Jul;36(7):1387-1402. 3. Alfos S, Boucheron C, et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcohol Clin Exp Res. 2001 Oct;25(10):1506-14.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max Nuclear Receptor Compound Library Neuronal Differentiation Compound Library

Related Products

Related compounds with same targets

ER 50891 Mofarotene MSU-42011 K-8012 CD3254 BMS493 Retinoic acid-d5 AGN 194310

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Keywords

CD2665 170355-78-9 Metabolism Retinoid Receptor CD-2665 inhibitor inhibit

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