Powder: -20°C for 3 years | In solvent: -80°C for 2 years
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 83.00 | |
5 mg | In stock | $ 167.00 | |
10 mg | In stock | $ 253.00 | |
25 mg | In stock | $ 425.00 |
Description | CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM. |
Targets&IC50 | RARβ:306 nM(ki), RARγ:(ki)110 nM |
In vitro | In 3T3 cells, CD2665 (100 nM) abrogates the antiproliferative effects of ATRA, CD271 (adapalene, a RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level[1]. |
In vivo | In mice submitted to 10 months of ethanol consumption, CD2665 (0.6 mg/kg; s.c.) decreases brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels[2]. |
Molecular Weight | 486.6 |
Formula | C31H34O5 |
CAS No. | 170355-78-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 22.5mg/mL (46.2mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CD2665 170355-78-9 Metabolism Retinoid Receptor CD-2665 inhibitor inhibit