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Adapalene sodium salt

Catalog No. T10246 CAS 911110-93-5

Synonyms: CD 271 sodium salt

Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.

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Adapalene sodium salt Chemical Structure

Adapalene sodium salt, CAS 911110-93-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.
Targets&IC50	RARβ:2.3 nM (AC50), RARγ:9.3 nM (AC50), RARα:22 nM (AC50)
In vitro	Adapalene sodium salt is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene sodium salt is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].
In vivo	Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin, and adapalene sodium salt group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than the adapalene sodium salt and controls (P < 0.05). Adapalene sodium salt was found to have an inhibition rate of 10.28%, and when compared with the other groups, it was found to have no statistically significant anti-inflammatory activity [2].

Synonyms	CD 271 sodium salt
Molecular Weight	435.519
Formula	C28H28NaO3
CAS No.	911110-93-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7. 2. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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Adapalene sodium salt 911110-93-5 Others Adapalene sodium CD 271 sodium salt CD 271 sodium inhibitor inhibit

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