pkr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16550	PKR-IN-C16		Others
	PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the A...		Others
T12499	PKR-IN-2		PKM
	PKR-IN-2 is a activator of pyruvate kinase (PKR).		PKM
T24647	PKR-IN-C51	PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51
	PKR-IN-C51 is an inhibitor of protein kinase R. It acts by correcting the aberrant splicing of MBNL1-dependent pre-mRNAs in DM1 cells without affecting the splicing pattern in normal non-DM1 cells.
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
T12498	PKR activator 2		Others
	PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).		Others
T12497	PKR activator 1		Others
	PKR activator 1 is a potent activator of pyruvate kinase-R (PKR).		Others
T75132	PKR activator 4
	PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].
T2614	GSK2606414		Apoptosis , PERK , Autophagy
	GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).		Apoptosis , PERK , Autophagy
T2654	GSK2656157		Apoptosis , PERK , Autophagy
	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 kinases.		Apoptosis , PERK , Autophagy
T21976	ONO-8130		Prostaglandin Receptor
	ONO-8130 is an orally available antagonist of EP1 receptor.		Prostaglandin Receptor
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T6183	ISRIB (trans-isomer)	ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis , PERK , Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).		Apoptosis , PERK , Autophagy
T63446	PKRA83
	PKRA83 is a potent prokineticin (PK2) antagonist that crosses the blood-brain barrier and competes for PK2 binding to its receptors PKR1 and PKR2. PKRA83 effectively inhibits PK2 receptors and acts on PKR1 (IC50: 5.0 nM)...
T81445	PKRA83 hydrochloride hydrate	PKRA7 hydrochloride hydrate
	PKRA83 hydrochloride hydrate, also known as PKRA7, is a potent prokineticin (PK2) antagonist that competes with PK2 for binding to its receptors, PKR1 and PKR2. It exhibits high inhibitory affinity with IC50 values of 5....
T7214	TEPP-46	ML265	PKM
	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .		PKM
T19836	2-Aminopurine		DNA/RNA Synthesis , PKA
	2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.		DNA/RNA Synthesis , PKA
T71825	BEPP monohydrochloride
	BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.
T26398	7DG	7-DG
	7DG is a selective inhibitor of protein kinase R (PKR).
T23813	Bozepinib
	Bozepinib is an antitumor compound that acts by inducing PKR-mediated apoptosis and synergizing with IFN.
T39753	Etavopivat	FT-4202
	Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling.