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Search Results for " pcna "

8

Compounds

Cat No. Product Name Synonyms Targets
T8955 PCNA-I1 Others
PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
T2764 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin,10-HCPT Apoptosis , Topoisomerase
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T6S1917 Schisandrol B Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B P450 , Reactive Oxygen Species , Autophagy
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...
T10343 AOH1160 N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide Apoptosis , DNA/RNA Synthesis
AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.
T35719 T2AA T2AA,4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol,ZINC95605533 DNA/RNA Synthesis
T2AA (4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol) is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction. T2AA suppresses cancer cell growth ...
T1757 ML-323 ML323 DUB
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I...
T77520 AOH1996 Apoptosis , DNA/RNA Synthesis
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...
T73560 I-138 DUB
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
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