10
12
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12376 | PC945 | Opelconazole | Others |
PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A/CYP51B), which can be used in the study of fungal infections of the lungs. | |||
T15650 | KDM5A-IN-1 | Histone Demethylase | |
KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 in... | |||
T1600 | Doxifluridine | Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine | Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by... | |||
T15649 | KDM5-IN-1 | Histone Demethylase | |
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM. | |||
T79394 | ALK/EGFR-IN-3 | ||
ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-EML4-ALK, with respective IC50 values of 0.1360, 0.0332, and... | |||
T62060 | NF-κB-IN-5 | ||
NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor. NF-κB-IN-5 interacts directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines, with IC 50 values of 5.35, 2.81, 2.83, 2.02 and... | |||
T79393 | ALK/EGFR-IN-2 | ||
ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines... | |||
T63492 | BI-1622 | ||
BI-1622 is a highly selective, orally active HER2(ERBB2) inhibitor (IC50: 7 nM). BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited hig... | |||
T61574 | PD-L1-IN-1 | ||
PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of periph... | |||
T6734 | WZ8040 | EGFR | |
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I). |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04966 | PCSK9 Protein, Human, Recombinant (D374Y, His) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05131 | PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-00408 | PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPJ-00443 | PCSK9 Protein, Macaca nemestrina, Recombinant (His) | Macaca nemestrina | Human Cells |
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in ... | |||
TMPJ-00368 | PCSK9 Protein, Human, Recombinant (Avi), Biotinylated | Human | Human Cells |
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processi... | |||
TMPJ-00369 | PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated | Human | Human Cells |
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processi... | |||
TMPY-01245 | PCSK9 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05217 | PCSK9 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05114 | PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05270 | PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05199 | PCSK9 Protein, Human, Recombinant (D374Y, mFc) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... | |||
TMPY-05218 | PCSK9 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec... |