Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A/CYP51B), which can be used in the study of fungal infections of the lungs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 167.00 | |
5 mg | In stock | $ 413.00 | |
10 mg | In stock | $ 689.00 | |
25 mg | In stock | $ 1,280.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 619.00 |
Description | PC945 (Opelconazole) is a potent broad-spectrum antifungal compound with inhibitory effect on fumonisinol 14α-demethylase (CYP51A/CYP51B), which can be used in the study of fungal infections of the lungs. |
Targets&IC50 | CYP51A:0.23 μM, CYP51B:0.22 μM |
In vitro | Designed for administration via inhalation, PC945 is a triazole antifungal[1]. PC945 demonstrates the most potent antifungal activity against the azole-susceptible strain NCPF2010, with a MIC value of 0.063 µg/mL[1]. |
In vivo | Substantially inhibiting the incidence of rolling behavior, PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) is observed[2]. |
Synonyms | Opelconazole |
Molecular Weight | 682.73 |
Formula | C38H37F3N6O3 |
CAS No. | 1931946-73-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (117.18 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PC945 1931946-73-4 Others PC-945 Opelconazole PC 945 inhibitor inhibit