Search Result

Search Results for " p19 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3635	IQ 1	IQ1,IQ-1	Wnt/beta-catenin
	IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.		Wnt/beta-catenin
TP1563	Gap19		Gap Junction Protein
	Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.		Gap Junction Protein
TP2110L	TAT-Gap19 acetate		Gap Junction Protein
	TAT-Gap19 acetate is a specific inhibitor of connexin43 hemichannel (Cx43 HC). TAT-Gap19 acetate traverses the blood-brain barrier and alleviates liver fibrosis in mice. TAT-Gap19 acetate does not inhibit the correspondi...		Gap Junction Protein
T3983	TMP195	TFMO 2,TMP 195	HDAC
	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.		HDAC
T41204	TAT-Gap19(I130A)	TAT-Gap19(I130A)
	TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expre...
T76273	Pep19-2.5
	Pep19-2.5, a synthetic antitoxin peptide, inhibits the intracellular signaling cascade triggered by endotoxins by blocking the activity of lipopeptides (LP) and lipopolysaccharides (LPS) mediated through both transmembra...
T36900	PD-1/PD-L1-IN-NP19	PD-1/PD-L1-IN-NP19	PD-1/PD-L1
	PD-1/PD-L1-IN-NP19, a PD-1/PD-L1 inhibitor, exhibits an IC50 of 12.5 nM against the human PD-1/PD-L1 interaction, potentially activating the tumor immune microenvironment and contributing to its antitumor effects[1].		PD-1/PD-L1
TP2110	TAT-Gap19
	Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of...
T75820	Gap19 TFA
	Gap19 TFA is a selective and potent blocker of connexin 43 (Cx43) hemichannels, originating from nine amino acids within the Cx43 cytoplasmic loop (CL). It operates by hindering intramolecular interactions between the C-...
T73571	CP19
	CP19, a histamine receptor antagonist, serves as an entry inhibitor for Ebolavirus (EBOV) and Marburgvirus (MARV), exhibiting inhibitory concentrations (IC50s) of 3.4 μM for EBOV and 29.5 μM for MARV, respectively. It de...
T75821	TAT-Gap19 TFA
	TAT-Gap19 TFA, a Cx mimetic peptide and specific connexin43 hemichannel (Cx43 HC) inhibitor, does not inhibit the corresponding Cx43 gap junction channels (GJCs). It crosses the blood-brain barrier and has been shown to ...
TP1511	Gap19 TFA (1507930-57-5 free base)	Gap19 TFA
	Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.
T76784	Tildrakizumab	MK 3222,SCH 900222	IL Receptor
	Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and ps...		IL Receptor
T76778	Risankizumab	Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor
	Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.R...		IL Receptor
T33652	Neurodazole
	Neurodazole is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.
T77088	Mirikizumab
	Mirikizumab (LY3074828), a humanized IgG4 monoclonal antibody, specifically targets the p19 subunit of interleukin 23. It is currently under research for its potential application in treating ulcerative colitis [1].
T61858	HDAC8-IN-3
	HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in le...
T76934	Brazikumab
	Brazikumab (AMG 139), a human IgG2 monoclonal antibody, selectively targets the p19 subunit of IL-23 with a dissociation constant (K D) of 0.138 nM, indicating high affinity for human IL-23. It is employed in Crohn's dis...

Compounds

IQ 1

T3635

Synonym: IQ1,IQ-1

Target: Wnt/beta-catenin

Gap19

TP1563

Synonym:

Target: Gap Junction Protein

TAT-Gap19 acetate

TP2110L

Synonym:

Target: Gap Junction Protein

TMP195

T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

TAT-Gap19(I130A)

T41204

Synonym: TAT-Gap19(I130A)

Synonym: PD-1/PD-L1-IN-NP19

Gap19 TFA (1507930-57-5 free base)

Synonym: MK 3222,SCH 900222

Target: IL Receptor

Risankizumab

T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04874	IL-23 P19/IL23A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST)	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPY-03526	IL-23 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.3 kDa and the accession number is Q9EQ14&P43432.
TMPY-04987	IL-23 P19/IL23A Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7.
TMPY-00406	IL-23 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-05247	IL-23 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-05648	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells...
TMPY-02215	Coagulation factor IX/F9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is AAB59620.1.
TMPY-05355	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.5 kDa and the accession number is P00740-1.
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b...
TMPY-01335	REG1A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPY-05474	REG1A Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPJ-00720	TXNDC12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defens...
TMPY-06190	SARS-CoV-2 Nucleocapsid Protein (P199L, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P199L, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPY-06219	SARS-CoV-2 Nucleocapsid Protein (P67S & P199L, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P67S & P199L, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPY-06220	SARS-CoV-2 Nucleocapsid Protein (P199L & M234I, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P199L & M234I, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.6 kDa and the accession number is P0DTC9.
TMPH-00956	Aromatase/CYP19A1 Protein, Human, Recombinant (His)	Human	E. coli
	Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00238	Lefty-A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma...