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TAT-Gap19 acetate

Catalog No. TP2110L   CAS TP2110L

TAT-Gap19 acetate is a specific inhibitor of connexin43 hemichannel (Cx43 HC). TAT-Gap19 acetate traverses the blood-brain barrier and alleviates liver fibrosis in mice. TAT-Gap19 acetate does not inhibit the corresponding Cx43 GJCs.

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TAT-Gap19 acetate Chemical Structure
TAT-Gap19 acetate, CAS TP2110L
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 197.00
10 mg In stock $ 338.00
25 mg In stock $ 597.00
50 mg In stock $ 852.00
100 mg In stock $ 1,170.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TAT-Gap19 acetate is a specific inhibitor of connexin43 hemichannel (Cx43 HC). TAT-Gap19 acetate traverses the blood-brain barrier and alleviates liver fibrosis in mice. TAT-Gap19 acetate does not inhibit the corresponding Cx43 GJCs.
In vivo TAT-Gap19 acetate (1 mg/kg/day) showed significantly decreased collagen deposition, as well as lower amounts of α-SMA-positive cells area in mice subjected to treatment with 100-200 mg thioacetamide (TAA)/kg body weight for eight weeks[1]. In 4 months old C57Bl6 male mice, TAT-Gap19 acetate (i.v.; 55 mg/kg) produces significant immune signal in the brain 24 h later[2].
Molecular Weight 2703.25
Formula C119H212N46O26
CAS No. TP2110L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Sara Crespo Yanguas, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19(3):817. 2. Laura Walrave, et al. Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents. Glia. 2018 Aug;66(8):1788-1804. 3. Verónica Abudara, et al. The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 2014 Oct 21;8:306.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
Carbenoxolone Meclofenamic acid sodium Peptide5 TFA Carvedilol phosphate hemihydrate Rotigaptide TFA(355151-12-1 free base) Gap19 Larazotide acetate Danegaptide Hydrochloride

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Keywords

TAT-Gap19 acetate TP2110L Cytoskeletal Signaling Gap Junction Protein TAT Gap19 acetate TAT-Gap19 Acetate TATGap19 acetate inhibitor inhibit

 

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