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Search Result

Search Results for " npm "

Targets

Apoptosis EGFR

7

Compounds

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T83641 HNPMI Apoptosis , EGFR
HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, may promote apoptosis, and may be used in the study of colorectal cancer.
T8399 Crizotinib hydrochloride PF-02341066 hydrochloride c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T1661 Crizotinib PF-02341066 c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T68538 CEP-14083
CEP-14083 is a potent ALK inhibitor that has shown activity in an NPM/ALK–carrying T-cell lymphoma in vitro study. Presumably, this compound binds to the hinge region of the kinase in an ATP-competitive manner. CEP-1408...
T83856 AP-1
AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as...
T16153 MS4078 ALK , Ligand for E3 Ligase , PROTACs
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
T37585 Ensartinib
Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or ...

Recombinant Proteins

Species：
Human (3)
Expression System：
E. coli (3)
Tag：
N-His (2)
N-6xHis-SUMO (1)
Cat No. Product Name Species Expression System
TMPY-01925 Nucleophosmin Protein, Human, Recombinant (His) Human E. coli
Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.
TMPY-04259 Nucleophosmin Protein, Human, Recombinant (aa 2-294, His) Human E. coli
Nucleophosmin Protein, Human, Recombinant (aa 2-294, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34 kDa and the accession number is P06748-1.
TMPH-01464 HNRNPM Protein, Human, Recombinant (His & SUMO) Human E. coli
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling ...
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