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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T78948 | NNRTIs-IN-1 | ||
NNRTIs-IN-1 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with notable anti-resistance efficacy, effectively inhibiting both the wild-type HIV-1 and five mutant strains at EC50 values within the nano... | |||
T78737 | NNRTIs-IN-3 | HIV Protease | |
NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 µM [1]. | |||
T64048 | HIV-IN-5 | ||
HIV-IN-5 (compound 5r) is a potent inhibitor of HIV-1 (IC50: 0.16 μM). HIV-IN-5 binds to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding sites). ). | |||
TN5012 | Shizukaol C | HIV Protease , Antifection | |
1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. 2. Shizukaol C has significant cytotoxicities against C8166 cells. |
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T64303 | ZLM-66 | ||
ZLM-66 is a doravirine analogue and a potent inhibitor of non-nucleoside reverse transcriptases (NNRTIs), acting on wild-type HIV-1 reverse transcriptase (IC50: 41 nM), wild-type HIV-1 (EC50: 13 nM) and cIAP1 (EC50: 0.32... | |||
TN5011 | Shizukaol B | ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production... |