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Search Result

Search Results for " nk1 "

92

Compounds

3

Natural Products

12

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T72224 NK1 receptor antagonist 2
NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.
T12233 NK-1 Antagonist 1 Rolapitant intermediate Others
NK-1 Antagonist 1 is a NK-1 receptor antagonist.
T78268 Anti-Mouse NK1.1 Antibody (PK136)
Anti-Mouse NK1.1 Antibody (PK136) is an IgG2a class antibody of murine origin targeting NK1.1, which eliminates NK1.1 and NK1.1NKT cells and inhibits NK1.1 signaling in peripheral blood, spleen, and lung tissues, and can...
T60733 MNK1/2-IN-5
MNK1/2-IN-5 is a potent and selective inhibitor of MNK1/2.
T73295 WNK1-IN-1
WNK1-IN-1, a selective inhibitor of WNK1, exhibits an IC50 value of 1.6 μM and also inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM, indicating its potential utility in the research of blood pressure regulatio...
T62686 MNK1/2-IN-6
MNK1/2-IN-6 is a potent and selective inhibitor of MNK1 (IC50: 2.3 nM), MNK2 (IC50: 3.4 nM), and MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.
T3716 Rolapitant SCH619734 Neurokinin receptor
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ...
T6905 Netupitant Ro 67-31898/000,CID 6451149 Neurokinin receptor
Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
T13306L Vapreotide acetate RC-160 acetate,BMY-41606 acetate Neurokinin receptor
Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
T13329 Vofopitant GR 205171 Neurokinin receptor
Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).
T13329L Vofopitant dihydrochloride GR 205171A,Vofopitant 2HCl Neurokinin receptor
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is...
TP1899L1 Hemokinin 1 (human) acetate(491851-53-7 free base) Neurokinin receptor
Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has prolifera...
TP2227L C14TKL-1 acetate Neurokinin receptor
C14TKL-1 acetate is a NK1 receptor agonist.
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base) Neurokinin receptor
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
T20413L Spantide acetate Spantide acetate(91224-37-2 Free base) Neurokinin receptor
Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.
T7828 [Sar9,Met(O2)11]-Substance P Bhsar-sp,NA Neurokinin receptor
[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.
TP1572 GR-73632 Neurokinin receptor
Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
T68068 Ezlopitant CJ 11974,CJ-11974,CJ11974 Neurokinin receptor
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
T7209 Maropitant Neurokinin receptor
Maropitant is a selective neurokinin (NK1) receptor antagonist.
T19518L Physalaemin acetate Neurokinin receptor
Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.
TP1369L [Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) Neurokinin receptor
[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (1...
T3724 Rolapitant hydrochloride Rolapitant HCl Neurokinin receptor
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride (Rolapitant HCl) does not interact with CY...
T68068L (R)-CJ 11974 Neurokinin receptor
(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induced vomiting.
T1790 Fosaprepitant dimeglumine L785298,MK-0517,Fosaprepitant dimeglumine salt Neurokinin receptor
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion...
T8235 L-732138 Neurokinin receptor
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
T1743 Aprepitant MK-869,MK-0869,L-754030,Aprepitant` HIV Protease , Antibacterial , Antibiotic , Neurokinin receptor
Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and C...
T78104 Fosnetupitant chloride monohydrochloride Pronetupitant chloride monohydrochloride Neurokinin receptor
Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for th...
T23345 SDZ NKT 343 Others
human tachykinin NK1 receptor antagonist
T22690 CP 96345 Others
CP 96345 is a NK1 receptor antagonist.
T22786 FK 888 Others
FK 888 is a selective, high-affinity tachykinin NK1 receptor antagonist.
T69295 DNK 333
DNK 333 is a dual neurokinin NK1/NK2 receptor antagonist.
T70416 PD 154075
PD 154075 is a a non-peptide tachykinin NK1 receptor antagonist.
TP2352 Septide Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)
Septide is an NK1 receptor agonist acting at a site distinct from substance P.
T22906 L 760735 Others
L 760735 is a NK1 receptor antagonist.
T35344 Maropitant citrate Neurokinin receptor
Maropitant citrate is a useful organic compound for research related to life sciences. The catalog number is T35344 and the CAS number is 359875-09-5.
T22811L GR 94800 acetate GR 94800 acetate (141636-65-9 free base) Neurokinin receptor
GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.
T27771 L-703606 Oxalate L 703606,L703,606,L-703,606,L703606,L 703,606,L-703606
L-703,606 is a potent, selective human NK1 receptor antagonist.
T29184 YM44778 YM-44778,YM 44778
YM44778 is a NK1-receptor antagonist for treating restless legs syndrome.
T10892 CS-003 Free base Neurokinin receptor
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base ...
T22902 L-733060 hydrochloride L-733,060 hydrochloride Others
Potent NK1 antagonist
T68519 Maropitant citrate anhydrous
Maropitant citrate anhydrous is a neurokinin (NK1) receptor antagonist.
T9471 Imnopitant
Imnopitant is an antagonist of the NK1 receptor [1].
T70137 CAM 4515
CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist.
T31039 CP-122721 UNII-R7OYP6N58F,CP122721
CP-122721 is an NK1 receptor antagonist with a unique antidepressant, anti-anxiety, and antiemetic properties. It is also an effective selective substance P receptor antagonist.
T23251 RP 67580 Others
tachykinin NK1 receptor antagonist
T22691 CP 99994 dihydrochloride Others
High affinity NK1 antagonist
T70132 HSP-117 dihydrochloride
HSP-117 dihydrochloride is a novel tachykinin NK1-receptor antagonist.
T27360 FR 113680 FR113680,FR-113680
FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.
T23385 SR 140333 Others
SR 140333 is a NK1 receptor antagonist.
T70410 Cam 2445
Cam 2445 is a nonpeptide, alpha-methyltryptophan derivative; an NK1 neurokinin receptor antagonist that is a potentially useful treatment for arthritis, asthma, migraine, anxiety, psychosis, and emesis.

Compounds

NK1 receptor antagonist 2
T72224
Synonym:
Target:
NK-1 Antagonist 1
T12233
Synonym: Rolapitant intermediate
Target: Others
Anti-Mouse NK1.1 Antibody (PK136)
T78268
Synonym:
Target:
MNK1/2-IN-5
T60733
Synonym:
Target:
WNK1-IN-1
T73295
Synonym:
Target:
MNK1/2-IN-6
T62686
Synonym:
Target:
Rolapitant
T3716
Synonym: SCH619734
Target: Neurokinin receptor
Netupitant
T6905
Synonym: Ro 67-31898/000,CID 6451149
Target: Neurokinin receptor
Vapreotide acetate
T13306L
Synonym: RC-160 acetate,BMY-41606 acetate
Target: Neurokinin receptor
Vofopitant
T13329
Synonym: GR 205171
Target: Neurokinin receptor
Vofopitant dihydrochloride
T13329L
Synonym: GR 205171A,Vofopitant 2HCl
Target: Neurokinin receptor
Hemokinin 1 (human) acetate(491851-53-7 free base)
TP1899L1
Synonym:
Target: Neurokinin receptor
C14TKL-1 acetate
TP2227L
Synonym:
Target: Neurokinin receptor
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
TP1772L
Synonym:
Target: Neurokinin receptor
Spantide acetate
T20413L
Synonym: Spantide acetate(91224-37-2 Free base)
Target: Neurokinin receptor
[Sar9,Met(O2)11]-Substance P
T7828
Synonym: Bhsar-sp,NA
Target: Neurokinin receptor
GR-73632
TP1572
Synonym:
Target: Neurokinin receptor
Ezlopitant
T68068
Synonym: CJ 11974,CJ-11974,CJ11974
Target: Neurokinin receptor
Maropitant
T7209
Synonym:
Target: Neurokinin receptor
Physalaemin acetate
T19518L
Synonym:
Target: Neurokinin receptor
[Sar9,Met(O2)11]-Substance P acetate
TP1369L
Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)
Target: Neurokinin receptor
Rolapitant hydrochloride
T3724
Synonym: Rolapitant HCl
Target: Neurokinin receptor
(R)-CJ 11974
T68068L
Synonym:
Target: Neurokinin receptor
Fosaprepitant dimeglumine
T1790
Synonym: L785298,MK-0517,Fosaprepitant dimeglumine salt
Target: Neurokinin receptor
L-732138
T8235
Synonym:
Target: Neurokinin receptor
Aprepitant
T1743
Synonym: MK-869,MK-0869,L-754030,Aprepitant`
Target: HIV Protease, Antibacterial, Antibiotic, Neurokinin receptor
Fosnetupitant chloride monohydrochloride
T78104
Synonym: Pronetupitant chloride monohydrochloride
Target: Neurokinin receptor
SDZ NKT 343
T23345
Synonym:
Target: Others
CP 96345
T22690
Synonym:
Target: Others
FK 888
T22786
Synonym:
Target: Others
DNK 333
T69295
Synonym:
Target:
PD 154075
T70416
Synonym:
Target:
Septide
TP2352
Synonym: Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)
Target:
L 760735
T22906
Synonym:
Target: Others
Maropitant citrate
T35344
Synonym:
Target: Neurokinin receptor
GR 94800 acetate
T22811L
Synonym: GR 94800 acetate (141636-65-9 free base)
Target: Neurokinin receptor
L-703606 Oxalate
T27771
Synonym: L 703606,L703,606,L-703,606,L703606,L 703,606,L-703606
Target:
YM44778
T29184
Synonym: YM-44778,YM 44778
Target:
CS-003 Free base
T10892
Synonym:
Target: Neurokinin receptor
L-733060 hydrochloride
T22902
Synonym: L-733,060 hydrochloride
Target: Others
Maropitant citrate anhydrous
T68519
Synonym:
Target:
Imnopitant
T9471
Synonym:
Target:
CAM 4515
T70137
Synonym:
Target:
CP-122721
T31039
Synonym: UNII-R7OYP6N58F,CP122721
Target:
RP 67580
T23251
Synonym:
Target: Others
CP 99994 dihydrochloride
T22691
Synonym:
Target: Others
HSP-117 dihydrochloride
T70132
Synonym:
Target:
FR 113680
T27360
Synonym: FR113680,FR-113680
Target:
SR 140333
T23385
Synonym:
Target: Others
Cam 2445
T70410
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T8789 N-Acetyl-L-tryptophan N-acetyltryptophan Endogenous Metabolite , Neurokinin receptor
N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).
T38033 Benzomalvin B
Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μ...
T71833 Acetylaszonalenin
Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM.

Natural Products

N-Acetyl-L-tryptophan
T8789
Synonym: N-acetyltryptophan
Target: Endogenous Metabolite, Neurokinin receptor
Benzomalvin B
T38033
Synonym:
Target:
Acetylaszonalenin
T71833
Synonym:
Target:

Recombinant Proteins

Species：
Human (8)
Mouse (4)
Expression System：
HEK293 Cells (8)
Baculovirus Insect Cells (2)
E. coli (1)
P. pastoris (Yeast) (1)
Tag：
N-6xHis (3)
C-His (2)
C-6xHis (1)
C-His-Avi (1)
His, GST (1)
N-GST (1)
N-mFc (1)
Tag Free (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-03290 HGF Protein, Mouse, Recombinant Mouse HEK293 Cells
HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.
TMPK-00062 CD160 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. CD160 antigenis a receptor on immune cells capable to...
TMPY-01905 CD160 Protein, Human, Recombinant (His) Human HEK293 Cells
CD160 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is O95971-1.
TMPY-05291 CD57/B3gat1 Protein, Human, Recombinant (mFc) Human HEK293 Cells
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited down...
TMPY-03237 HGF Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.
TMPJ-00220 B3GAT1 Protein, Human, Recombinant (His) Human HEK293 Cells
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. It adds a glucuronic residue to the terminal lact...
TMPY-04554 JNK1 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellula...
TMPY-04402 CSNK1G1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ...
TMPJ-00733 SPINK1 Protein, Human, Recombinant (His) Human HEK293 Cells
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A dise...
TMPY-02381 NK1.1/KLRB1F Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
NK1.1/KLRB1F Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is Q8VD98.
TMPH-02897 SPINK1 Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulat...
TMPH-01054 CSNK1E Protein, Human, Recombinant (His) Human E. coli
CSNK1E Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.3 kDa and the accession number is P49674.
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