mer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38936	KRAS G13D peptide, 25 mer	KRAS G13D peptide, 25 mer
	KRAS G13D peptide, a 25-mer sequence, is derived from the KRAS activating oncogene mutation and serves as an immune potentiator. This peptide possesses immunogenic properties and can be utilized for the development of a ...
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T0318	Azacyclonol	Ataractan,γ-pipradol,MDL 4829,MER 17	5-HT Receptor
	Azacyclonol (MER 17) is a drug used to diminish hallucinations in psychotic individuals.		5-HT Receptor
T72574	Axl/Mer/CSF1R-IN-1
	Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.
T13074	TAM-IN-2		TAM Receptor
	TAM-IN-2 is an inhibitor of TAM.		TAM Receptor
T1968	UNC2250		TAM Receptor
	UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).		TAM Receptor
T83852	EGFRvIII Peptide TFA	PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide, a synthetic peptide mirroring the EGFRvIII fusion junction—a tumor-specific, perpetually active EGFR variant missing amino acids 6-273 of the wild-type—binds to HLA-A*0201-positive T2 cells under MHC cl...
T6982	SGI-7079		FLT , c-Met/HGFR , c-RET , TAM Receptor , Src
	SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.		FLT , c-Met/HGFR , c-RET , TAM Receptor , Src
T2311	LDC1267		TAM Receptor
	LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).		TAM Receptor
T17205	UNC2541		Others , FLT , TAM Receptor
	UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor. It also binds in the MerTK ATP pocket (IC50: 4.4 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).		Others , FLT , TAM Receptor
T2005	Dubermatinib	TP0903	Apoptosis , TAM Receptor
	Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.		Apoptosis , TAM Receptor
TQ0041	Ningetinib Tosylate		VEGFR , c-Met/HGFR , TAM Receptor
	Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.		VEGFR , c-Met/HGFR , TAM Receptor
T2629	UNC2881		TAM Receptor
	UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.		TAM Receptor
T6907	NPS-1034	NPS1034,NPS 1034	Apoptosis , c-Met/HGFR , TAM Receptor
	NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.		Apoptosis , c-Met/HGFR , TAM Receptor
T7425	RU-301		TAM Receptor
	RU-301 is a novel pan-tam inhibitor		TAM Receptor
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T21302	UNC569	UNC 569	TAM Receptor
	UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun...		TAM Receptor
T70265	AL-6556
	AL-6556 is a prostaglandin DP receptor agonist.
T9123	DS-1205		TAM Receptor
	DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...		TAM Receptor
T4426	CEP-40783	CEP 40783,RXDX-106	c-Met/HGFR , TAM Receptor
	CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).		c-Met/HGFR , TAM Receptor