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UNC569

Catalog No. T21302 CAS 1350547-65-7

Synonyms: UNC 569

UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.

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UNC569, CAS 1350547-65-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 538.00
100 mg	In stock	$ 768.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.
Targets&IC50	Mer:2.9 nM(IC50), Mer:4.3 nM(Ki), Axl:37 nM(IC50)

Synonyms	UNC 569
Molecular Weight	396.5
Formula	C22H29FN6
CAS No.	1350547-65-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (75.66 mM), Sonication is recommended.

H2O: Insoluble

References and Literature

1. Christoph S, Deryckere D, Schlegel J, Frazer JK, Batchelor LA, Trakhimets AY, Sather S, Hunter DM, Cummings CT, Liu J, Yang C, Kireev D, Simpson C, Norris-Drouin J, Hull-Ryde EA, Janzen WP, Johnson GL, Wang X, Frye SV, Earp HS 3rd, Graham DK. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov;12(11):2367-77. doi: 10.1158/1535-7163.MCT-13-0040. Epub 2013 Aug 30. PubMed PMID: 23997116; PubMed Central PMCID: PMC3823742.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Inhibitor Library Hematonosis Compound Library Bioactive Compounds Library Max Orally Active Compound Library NO PAINS Compound Library Bioactive Compound Library

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Related compounds with same targets

AXL-IN-15 Cabozantinib hydrochloride SGI-7079 Axl-IN-16 AXL-IN-13 Sitravatinib Emactuzumab CEP-40783

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC569 1350547-65-7 Tyrosine Kinase/Adaptors TAM Receptor anti-oncogenic Inhibitor UNC-569 ATP-competitive ALL Tyro3 AKT ERK Mer inhibit pyrazolopyrimidine Axl UNC 569 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.