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LDC1267

Catalog No. T2311   CAS 1361030-48-9

LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).

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LDC1267 Chemical Structure
LDC1267, CAS 1361030-48-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 44.00
5 mg In stock $ 70.00
10 mg In stock $ 107.00
25 mg In stock $ 177.00
50 mg In stock $ 261.00
100 mg In stock $ 441.00
1 mL * 10 mM (in DMSO) In stock $ 85.00
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Purity: 99.76%
Purity: 99.44%
Purity: 99.42%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
Targets&IC50 Axl:29 nM, Mer:<5 nM, Tyro3:8 nM
Kinase Assay Kinase binding assays: For optimization of Axl/TAM receptor inhibitors, an Axl binding assay is established (HTRF method; Kinase tracer 236). This assay is based on the binding and displacement of the Alexa Fluor 647-labelled Kinase tracer 236 to each glutathione S-transferase (GST)-tagged kinase used in the binding assay. Binding of the tracer to the kinase was detected by using europium (Eu)-labelled anti-GST antibodies. Simultaneous binding of both the fluorescent tracer and the Eu-labelled antibodies to the GST-tagged kinase generates a fluorescence resonance energy transfer (FRET) signal. Binding of inhibitor to the kinase competes for binding with the tracer, resulting in a loss of the FRET signal. For the assay, the compound is diluted in 20?mM HEPES, pH?8.0, 1?mM DTT, 10?mM MgCl2 and 0.01% Brij35. Then, the kinase of interest (5?nM final concentration), fluorescent tracer (15?nM final concentration) and LanthaScreen Eu-anti-GST antibody (2?nM final concentration) are mixed with the respective compound dilutions (from 5?nM to 10?μM) and incubated for 1?h. The FRET signal is quantified using an EnVision Multilabellreader 2104.
Cell Research After incubation for 72?hours with LDC1267, CellTiterGlow reagent is used to determine the proliferation relative to the corresponding DMSO control.(Only for Reference)
Molecular Weight 560.55
Formula C30H26F2N4O5
CAS No. 1361030-48-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (165.9 mM)

Ethanol: 2 mg/mL (3.56 mM), warmed

TargetMolReferences and Literature

1. Paolino M, et al. Nature. 2014, 507(7493), 508-512.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Highly Selective Inhibitor Library Kinase Inhibitor Library Inhibitor Library Immunology/Inflammation Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library Fluorochemical Library Bioactive Compound Library

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Keywords

LDC1267 1361030-48-9 Tyrosine Kinase/Adaptors TAM Receptor LDC-1267 LDC 1267 Tyro3 Inhibitor inhibit Axl Mer inhibitor

 

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