16
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T71346 | MS4 | ||
MS4 is a novel glucocorticoid receptor (GR) agonist with anti-inflammatory activity and displaying reduced impact on islets. | |||
T16153 | MS4078 | ALK , Ligand for E3 Ligase , PROTACs | |
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK. | |||
T16154 | MS417 | GTPL7512 | Epigenetic Reader Domain , HIV Protease |
MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM. | |||
T12112 | MS402 | Epigenetic Reader Domain | |
MS402 is a novel BD1-selective BET BrD inhibitor. | |||
T21714 | BMS453 | BMS 453,BMS-189453 | Retinoid Receptor |
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. | |||
T14689 | BMS493 | BMS-493 | Phospholipase , Retinoid Receptor |
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates ... | |||
T40233 | (Iso)-MS4322 | (Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer) | Histone Methyltransferase , PROTACs |
(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits th... | |||
T9146 | ms48107 | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- | Others |
MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch... | |||
T1854 | MS436 | Epigenetic Reader Domain | |
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains. | |||
T28116 | MS453 | MS-453,MS 453 | |
MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM. | |||
T24502 | MS437 | MS 437,MS-437 | |
MS437 is a potent TSH receptor agonist. | |||
T73433 | MS47134 | ||
MS47134, a selective and potent MRGPRX4 agonist, exhibits an EC50 of 149 nM and holds potential for researching pain, itch, and mast cell-mediated hypersensitivity. | |||
T82378 | Folate-MS432 | PROTACs | |
Folate-MS432 is a PROTAC that degrades MEKs selectively in cancer cells via folate receptor-dependent pathways. | |||
T13781 | MS4077 | ALK , PROTACs | |
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK). | |||
T24503 | MS438 | MS-438,MS 438 | |
MS438 is an effective agonist of the TSH receptor. | |||
T13782 | MS432 | MEK , PROTACs | |
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. |