mgc-803 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13349	WS-383		E1/E2/E3 Enzyme
	WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).		E1/E2/E3 Enzyme
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T77584	Tubulin inhibitor 35	Tubulin IN 35	Apoptosis , Microtubule Associated , Topoisomerase
	Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts...		Apoptosis , Microtubule Associated , Topoisomerase
T2897	(Rac)-Shikonin	(±)-Shikonin,Alkanet extract,Anchusin,Anchusa acid	Others
	(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics,...		Others
T4958	(-)-Alkannin	Alkannin,Shikonin	Apoptosis , PI3K
	(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a...		Apoptosis , PI3K
T60852	Anticancer agent 46
	Anticancer agent 46 is a potent anti-cancer agent, showing anti-proliferative activity in cellular assays, with an IC50 of 0.986 μM against MGC803 cells.
T64014	Antitumor agent-58
	Antitumor agent-58 is an antitumour agent that effectively inhibits colony formation and cell migration in MGC-803 cells and induces mitochondrial dysfunction in MGC-803 cells. Antitumor agent-58 exhibited potent inhibit...
T78909	Antitumor agent-97		Apoptosis
	Antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in MGC 803 cells, induces apoptosis, and enhances ROS accumulation, proving useful in cancer research [1].		Apoptosis
T62445	Tubulin inhibitor 22
	Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin that exhibits anti-angiogenic and anti-cancer activity. tubulin inhibitor 22 blocks the cell cycle of MGC-803 cells in the G2/M phase. tubulin inhibitor...
TN5204	Uralsaponin C		Others
	Uralsaponin C shows the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μmol/L.		Others
T61369	P53 Activator 2
	p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant DNA double-strand breaks and upregulates the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces ...
TN1865	Licoricesaponin A3		Others
	Licoricesaponin A3 shows the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μMol/L.		Others
T81856	Marsdenoside B
	Marsdenoside B (compound 8), an isolate from the Alocasia genus, exhibits antitumor activity by inhibiting the proliferation of MGC-803 and HT-29 tumor cell lines with IC50 values of 25.6 μg/mL and 32.4 μg/mL, respective...
T61773	Keap1-Nrf2-IN-4
	Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, i...
T82782	Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside
	Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12), a cardiac glycoside extracted from Thevetia peruviana seeds, exhibits cytotoxic effects on SW1990 and MGC-803 cells with IC50 values of 9.52 and 7.70 μM,...
T81857	Marsdenoside A
	Marsdenoside A (compound 7), an isolated compound from the Alocasia genus, exhibits a weak inhibitory effect on the growth of two tumor cell lines, MGC-803 and HT-29, with IC50 values exceeding 50 μg/mL.
T74858	LSD1-IN-26
	LSD1-IN-26 (compound 12u), a potent LSD1 inhibitor, exhibits an IC50 of 25.3 nM. It also demonstrates inhibition of MAO-A (IC50 = 1234.57 nM) and MAO-B (IC50 = 3819.27 nM), significantly inducing apoptosis in MGC-803 cel...
T82420	FAK-IN-12		FAK
	FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with IC50 values of 0.24, 0.45, and 0.44 μM, respectively. Additi...		FAK