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Search Results for " indirubin "

11

Compounds

Cat No. Product Name Synonyms Targets
T6169 Indirubin Indigopurpurin,Indigo red,NSC 105327,Couroupitine B Apoptosis , Raf , GSK-3 , CDK
Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
T9138 Indirubin-3′-oxime Indirubin-3'-monoxime GSK-3 , CDK , JNK
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
T5200 Indirubin-3'-monoxime Indirubin-3'-oxime GSK-3 , Lipoxygenase , CDK
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
T11654 Indirubin Derivative E804 Others
Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65.
T11653 Indirubin-5-sulfonate Others
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli...
T11652 Indirubin-3'-monoxime-5-sulphonic acid Others
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.
T10172 5-Iodo-indirubin-3'-monoxime GSK-3 , CDK
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25 nM).
T1882 Meisoindigo N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III Apoptosis
Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
T19866 Indican NSC-87517,3-Indoxyl-beta-D-glucopyranoside,NSC 87517,NSC87517,Indoxyl-β-D-glucoside OAT , MRP
Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
T8317 5'-Fluoroindirubinoxime 5'-FIO FLT
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
T79777 GPX4-IN-7 Ferroptosis
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound ...
TargetMol