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Indican

Catalog No. T19866 CAS 487-60-5

Synonyms: NSC-87517, 3-Indoxyl-beta-D-glucopyranoside, NSC 87517, NSC87517, Indoxyl-β-D-glucoside

Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.

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Indican, CAS 487-60-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 42.00
100 mg	In stock	$ 57.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
In vitro	Oral single doses of Indican at 20, 40 mg/kg increase the systemic exposure of MTX and MRT by inhibiting multiple anion transporters including OAT 1, OAT 3, and MRP 4 via the major metabolite indoxyl sulfate (IS) [3].

Synonyms	NSC-87517, 3-Indoxyl-beta-D-glucopyranoside, NSC 87517, NSC87517, Indoxyl-β-D-glucoside
Molecular Weight	295.29
Formula	C14H17NO6
CAS No.	487-60-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 8 mg/mL (27.09 mM)

DMSO: 88 mg/mL (298.01 mM)

References and Literature

1. Kamiński T, Michałowska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review. 2. Wu CC, Hung SC, Kuo KL, Tarng DC. Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access. Toxins (Basel). 2017 Jan 7;9(1). pii: E25. 3. Gao H, Liu S. Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease. Life Sci. 2017 Sep 15;185:23-29. doi: 10.1016/j.lfs.2017.07.027. Epub 2017 Jul 25. Review. PubMed PMID: 28754616. 4. Gao H, Liu S. Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease. Life Sci. 2017 Sep 15;185:23-29.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Traditional Chinese Medicine Monomer Library Inhibitor Library Natural Product Library for HTS RO5 Drug-like Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Saccharide and Glycoside Natural Product Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Indican 487-60-5 Immunology/Inflammation Membrane transporter/Ion channel OAT MRP toxin sulfate NSC-87517 MRP4 Inhibitor Indoxyl-b-D-glucoside uremic 3-Indoxyl-beta-D-glucopyranoside anion inhibit 3-Indoxyl-β-D-glucopyranoside dyesindigo indoxyl transporter 3-Indoxyl-b-D-glucopyranoside indirubin OAT3 organic glycoside， indoxyl NSC 87517 Indoxyl-beta-D-glucoside OAT1 NSC87517 Indoxyl-β-D-glucoside inhibitor

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