ibs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5491	GSK3179106		c-RET
	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM		c-RET
T1460	Dicyclomine hydrochloride		AChR
	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.		AChR
T40481	IBS008738
	IBS008738, a potent TAZ activator, stabilizes TAZ, elevates the unphosphorylated TAZ level, enhances the interaction of MyoD with the myogenin promoter, upregulates gene transcription regulated by MyoD, and competes with...
T1006	Propantheline bromide	Neopepulsan,Pro-Banthine,Neometantyl	AChR
	Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid...		AChR
T1551	Tegaserod maleate	HTF-919,SDZ-HTF-919	5-HT Receptor
	Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ...		5-HT Receptor
T3178	BIBS 39		RAAS
	BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.		RAAS
T68802	Vibsanin A
	Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.
TN5231	Vibsanin C		Others
	Vibsanin C is a natural product of Viburnum, Caprifoliaceae. The catalog number is TN5231 and the CAS number is 74690-89-4. Vibsanin C can be used as a reference standard.		Others
T26802	BIBS-222	BIBS 222
	BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat.
T11852	Linaclotide		Guanylate cyclase
	Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.		Guanylate cyclase
T60680	Tegaserod		5-HT Receptor
	Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable ...		5-HT Receptor
TN6791	Palvanil	Hexadecanamide	TRP/TRPV Channel
	Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and reduces visceral pain.		TRP/TRPV Channel
T38507	Renzapride	BRL 24924	5-HT Receptor
	Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).		5-HT Receptor
T0918	Trimebutine	Mebutin	Opioid Receptor
	Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...		Opioid Receptor
T21235	Alosetron	Lotronex,GR68755,GR-68755,GR 68755
	Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.
T24887	Tiropramide	CR-605
	Tiropramide is an antispasmodic drug. It also useful to inhibit the contractile response of the urinary bladder and in managing abdominal pain in IBS.
T13002	SSR-241586		Others
	SSR-241586 is a neurokinin receptors antagonist,and is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS).		Others
T30936	Cilansetron Hydrochloride	KC-9946,KC9946,KC 9946
	Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance.
T38482	MM 419447
	MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
T64234	Alosetron (Hydrochloride(1:X))
	Alosetron (GR 68755) Hydrochloride (1:X) is a potent and highly selective 5-HT3 receptor antagonist with anti-inflammatory effects. Alosetron Hydrochloride (1:X) can be used in the study of irritable bowel syndrome (IBS)...