hif-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11561	HIF-2α-IN-2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).		HIF/HIF Prolyl-Hydroxylase , HIF
T67831	HIF-2α agonist 2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reh...		HIF/HIF Prolyl-Hydroxylase , HIF
T61349	HIF-1α-IN-2		HIF
	HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration.		HIF
T64336	Izilendustat		HIF/HIF Prolyl-Hydroxylase
	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.		HIF/HIF Prolyl-Hydroxylase
T1823	IOX2	IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase
	IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).		HIF/HIF Prolyl-Hydroxylase
T3289	Amifostine	Ethyol,WR2721,Gammaphos	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.		Others , HIF/HIF Prolyl-Hydroxylase
T2941	Glucosamine hydrochloride	Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride	Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
	Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T1101	Minocycline hydrochloride	Minocycline HCl	HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...		HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
T61458	HIF-PHD-IN-2
	HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
T61102	HIF-1/2α-IN-2
	HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur ...
T78123	HIF-1α-IN-2 hydrochloride		HIF/HIF Prolyl-Hydroxylase
	HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF-1α expression by...		HIF/HIF Prolyl-Hydroxylase
T61822	M1002		HIF
	M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and ac...		HIF
T22022	Adaptaquin		HIF
	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].		HIF
T12675L	PT2399		HIF/HIF Prolyl-Hydroxylase , HIF
	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).		HIF/HIF Prolyl-Hydroxylase , HIF
T4106	MK-8617	MK8617	HIF/HIF Prolyl-Hydroxylase
	MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).		HIF/HIF Prolyl-Hydroxylase
T3180	JNJ-42041935	HIF-PHD Inhibitor II	HIF/HIF Prolyl-Hydroxylase
	JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.		HIF/HIF Prolyl-Hydroxylase
T6961	PX-478	PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
	PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...		HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
T2445	FG-2216	YM-311,FG2216,FG 2216	HIF/HIF Prolyl-Hydroxylase
	FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.		HIF/HIF Prolyl-Hydroxylase
T67836	AT-533		HSP , HSV
	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i...		HSP , HSV