20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2544 | Bazedoxifene acetate | WAY-TES 424,TSE 424,WAY-140424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). | |||
T6404 | Bazedoxifene hydrochloride | Bazedoxifene HCl,TSE-424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. | |||
T26537 | AC-186 | AC186,AC 186 | Estrogen/progestogen Receptor |
AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study o... | |||
T7644 | DPN | Diarylpropionitrile | Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy |
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) . | |||
T13443 | (R)-Equol | (+)-Equol | Estrogen/progestogen Receptor |
(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively. | |||
T3846 | Bavachin | Corylifolin | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ. | |||
T13674 | Elacestrant | RAD1901 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . | |||
T11915 | LY88074 | Estrogen/progestogen Receptor | |
LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation. | |||
T6533 | Hexestrol | Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. | |||
T23540 | Y134 | Y 134 | Estrogen Receptor/ERR , Others |
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121... | |||
T13675 | Elacestrant dihydrochloride | RAD1901 dihydrochloride | Estrogen/progestogen Receptor |
Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively. | |||
T4000 | (±)-Equol | Equol,(R,S)-Equol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite |
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu... | |||
T4388 | PHTPP | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PHTPP is a selective ERβ antagonist. | |||
T10239 | Acolbifene | EM-652,SCH 57068 | Estrogen Receptor/ERR |
Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property. | |||
T9800 | Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- | Estrogen/progestogen Receptor | |
Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- is an estrogen receptor beta (ERβ) agonist. | |||
T16566 | Propyl pyrazole triol | PPT | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ... | |||
T1048 | Estradiol | E2,17β-Estradiol,17β-Oestradiol,β-Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... | |||
T3325 | Liquiritigenin | 4',7-Dihydroxyflavanone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. | |||
T22794 | G36 | G-36 | Estrogen Receptor/ERR |
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to... | |||
T2250 | DY131 | DY 131,GSK 9089,DY-131 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo |
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ. |