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Propyl pyrazole triol

Catalog No. T16566 CAS 263717-53-9

Synonyms: PPT

Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).

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Propyl pyrazole triol Chemical Structure

Propyl pyrazole triol, CAS 263717-53-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 279.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 743.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98.39%

Biological Description

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Description	Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).
Targets&IC50	ERα:140 pM(EC50)
In vitro	In ERα-U2OS-Luc cells, the EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM[1].

Synonyms	PPT
Molecular Weight	386.44
Formula	C24H22N2O3
CAS No.	263717-53-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (256.18 mM)

References and Literature

1. Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells. 2. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Human Metabolite Library Endocrinology-Hormone Compound Library Nuclear Receptor Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Ovarian Cancer Compound Library

Related Products

Related compounds with same targets

(20S)-Protopanaxatriol Bazedoxifene acetate GSK5182 Chrysin ARV-471 Mestranol Estradiol kaempferide

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Keywords

Propyl pyrazole triol 263717-53-9 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR inhibit Inhibitor PPT inhibitor

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