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LY88074

Catalog No. T11915 CAS 177744-96-6

LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.

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LY88074, CAS 177744-96-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 329.00
5 mg	In stock	$ 798.00
10 mg	In stock	$ 1,090.00
25 mg	In stock	$ 1,650.00
50 mg	In stock	$ 2,230.00
100 mg	In stock	$ 2,930.00
1 mL * 10 mM (in DMSO)	In stock	$ 942.00

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Purity: 98.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.
Targets&IC50	ERβ:232 nM(EC50)
In vitro	The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene.Removal of the aminoethylpiperdine moiety, as in LY88074, reduces bone binding, compared to Raloxifene[3].

Molecular Weight	362.4
Formula	C21H14O4S
CAS No.	177744-96-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.62 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Dai SY, et al. Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange. Biochemistry. 2009 Oct 13;48(40):9668-76. 2. Dai SY, et al. Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7171-6. 3. Bivi N, et al. Structural features underlying raloxifene's biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY88074 177744-96-6 Endocrinology/Hormones Estrogen/progestogen Receptor LY-88074 LY 88074 inhibitor inhibit

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