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Hexestrol

Name: Hexestrol
Brand: TargetMol
SKU: T6533
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: meso-Hexestrol, Hexestrofen, Hexanoestrol) Copy Product Info

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Synonyms: meso-Hexestrol, Hexestrofen, Hexanoestrol

Catalog No. T6533 Copy Product Info

Purity: 99.2%

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Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Cas No. 84-16-2

Pack Size	Price	USA Stock	Global Stock
100 mg	$47	In Stock	In Stock
200 mg	$68	-	In Stock
500 mg	$112	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.2%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Targets & IC50	ERβ:0.175 nM(EC50), ERα:0.07 nM(EC50)
In vitro	Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]
In vivo	Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]
Synonyms	meso-Hexestrol, Hexestrofen, Hexanoestrol

Chemical Properties

Molecular Weight	270.37
Formula	C₁₈H₂₂O₂
Cas No.	84-16-2
Smiles	[C@H]([C@H](CC)C1=CC=C(O)C=C1)(CC)C2=CC=C(O)C=C2
Relative Density.	1.093 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (203.42 mM), Sonication is recommended.

Ethanol: 39 mg/mL (144.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 5.5 mg/mL (20.34 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.5 mg/mL (20.34 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6986 mL	18.4932 mL	36.9864 mL	184.9318 mL
5 mM	0.7397 mL	3.6986 mL	7.3973 mL	36.9864 mL
10 mM	0.3699 mL	1.8493 mL	3.6986 mL	18.4932 mL
20 mM	0.1849 mL	0.9247 mL	1.8493 mL	9.2466 mL
50 mM	0.0740 mL	0.3699 mL	0.7397 mL	3.6986 mL
100 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8493 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc