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AC-186

Catalog No. T26537 CAS 1421854-16-1

Synonyms: AC186, AC 186

AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AC-186, CAS 1421854-16-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 81.00
5 mg	In stock	$ 129.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 342.00
50 mg	In stock	$ 488.00
100 mg	In stock	$ 712.00
500 mg	In stock	$ 1,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 167.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.
Targets&IC50	ERβ:6 nM (EC50), ERα:5000 nM (EC50)
In vitro	In LNCaP cells, AC-186 (10 μM; 72 hours) inhibits the growth of LNCaP cells[1].
In vivo	In male Sprague-Dawley rats weighing 225-250 g, AC-186 (10 mg/kg; s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, but had no effect in females[1].

Synonyms	AC186, AC 186
Molecular Weight	306.32
Formula	C18H17F3O
CAS No.	1421854-16-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (261.16 mM), Sonication is recommended.

References and Literature

1. McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55. 2. Jian-Nong Ma, et al. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7(9):1180-7. 3. George S, Petit GH, Gouras GK, Brundin P, Olsson R. Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem Neurosci. 2013 Dec 18;4(12):1537-48. 4. Itoh N,et al. Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis. J Neuroimmunol. 2017 Mar 15;304:63-71.

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Keywords

AC-186 1421854-16-1 Endocrinology/Hormones Estrogen/progestogen Receptor AC186 AC 186 inhibitor inhibit

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