dubs — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4067	VLX1570		DUB
	VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.		DUB
T14852	C527		DUB
	C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).		DUB
T11112	DUB-IN-3		DUB
	DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.		DUB
T11111	DUB-IN-2		DUB
	Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.		DUB
T11110	DUB-IN-1		DUB
	DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).		DUB
T9122	XL177A		DUB
	XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.		DUB
T36682	USP30 inhibitor 18		DUB
	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...		DUB
T11209	EOAI3402143		DUB
	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.		DUB
T9375	IU1-248		DUB
	IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].		DUB
T5461	GNE-6640		DUB
	GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23...		DUB
T15729	LDN-91946		DUB
	LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).		DUB
T15604	IU1-47		DUB
	IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).		DUB
T15464	HBX 19818		DUB
	HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).		DUB
T3555	ML364		DUB
	ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.		DUB
T12024	MF-094		DUB
	MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).		DUB
T13268	USP7-IN-1		DUB
	USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).		DUB
T2424	P 22077	P22077	DUB
	P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.		DUB
T1757	ML-323	ML323	DUB
	ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (I...		DUB
T6107	IU1		DUB , Autophagy
	IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.		DUB , Autophagy
T1924	LDN-57444	LDN57444	Apoptosis , DUB
	LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .		Apoptosis , DUB