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DUB-IN-3

Catalog No. T11112 CAS 924296-17-3

DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DUB-IN-3, CAS 924296-17-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 139.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 343.00
10 mg	In stock	$ 490.00
25 mg	In stock	$ 783.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,950.00
1 mL * 10 mM (in DMSO)	In stock	$ 359.00

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Purity: 99.34%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
Targets&IC50	USP8:0.56 μM

Molecular Weight	287.28
Formula	C16H9N5O
CAS No.	924296-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 24 mg/mL (83.54 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

Related compound libraries

This product is contained In the following compound libraries：

HIF-1 Signaling Pathway Compound Library Bioactive Compounds Library Max NO PAINS Compound Library DNA Damage & Repair Compound Library Bioactive Compound Library Ubiquitination Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library Inhibitor Library

Related Products

Related compounds with same targets

USP5-IN-1 USP8-IN-3 USP8-IN-2 USP8-IN-1 USP22-IN-1 KSQ-4279 SJB3-019A USP15-IN-1

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DUB-IN-3 924296-17-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB DUBs inhibit Deubiquitinase DUBIN3 Inhibitor DUB IN 3 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.