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LDN-91946

Catalog No. T15729 CAS 439946-22-2

LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).

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LDN-91946, CAS 439946-22-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
Targets&IC50	UCH-L1: 2.8 μM(ki)
In vitro	LDN-91946 shows no activity against TGase 2, Papain, and Caspase-3 at 40 μM. LDN-91946 is inactive against UCH-L3 at 20 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].

Molecular Weight	314.32
Formula	C15H10N2O4S
CAS No.	439946-22-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 83 mg/mL (264.06 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LDN-91946 439946-22-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor Ubiquitin LDN 91946 inhibit Deubiquitinase UCH-L1 DUBs selective LDN91946 inhibitor

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