Powder: -20°C for 3 years
In solvent: -80°C for 2 years
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
Description | LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM). |
Targets&IC50 | UCH-L1: 2.8 μM(ki) |
In vitro | LDN-91946 shows no activity against TGase 2, Papain, and Caspase-3 at 40 μM. LDN-91946 is inactive against UCH-L3 at 20 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1]. |
Molecular Weight | 314.32 |
Formula | C15H10N2O4S |
CAS No. | 439946-22-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 83 mg/mL (264.06 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LDN-91946 439946-22-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor Ubiquitin LDN 91946 inhibit Deubiquitinase UCH-L1 DUBs selective LDN91946 inhibitor