Powder: -20°C for 3 years
In solvent: -80°C for 2 years
C527 is a is a pan <a href="/target/DUB" style="display: inline; color: #c13a36">DUB</a> enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 90.00 | |
25 mg | In stock | $ 189.00 | |
50 mg | In stock | $ 308.00 | |
100 mg | In stock | $ 515.00 | |
200 mg | In stock | $ 783.00 |
Description | C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM). |
Targets&IC50 | USP1:0.88 μM |
In vitro | C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI and it also lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents[1]. Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC50 of 0.88±0.03 μM. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. |
Molecular Weight | 293.25 |
Formula | C17H8FNO3 |
CAS No. | 192718-06-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 65 mg/ml (221.65 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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C527 192718-06-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor C 527 DUBs Deubiquitinase C-527 inhibit inhibitor