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C527

Catalog No. T14852 CAS 192718-06-2

C527 is a is a pan <a href="/target/DUB" style="display: inline; color: #c13a36">DUB</a> enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).

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C527, CAS 192718-06-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 50.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 90.00
25 mg	In stock	$ 189.00
50 mg	In stock	$ 308.00
100 mg	In stock	$ 515.00
200 mg	In stock	$ 783.00

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Purity: 97.64%

Biological Description

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Storage & Solubility Information

Description	C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
Targets&IC50	USP1:0.88 μM
In vitro	C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI and it also lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents[1]. Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC50 of 0.88±0.03 μM. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin.

Molecular Weight	293.25
Formula	C17H8FNO3
CAS No.	192718-06-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 65 mg/ml (221.65 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mistry H, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec;12(12):2651-62.

Related compound libraries

This product is contained In the following compound libraries：

DNA Damage & Repair Compound Library HIF-1 Signaling Pathway Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library Inhibitor Library Ubiquitination Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

USP8-IN-2 USP8-IN-3 USP15-IN-1 IMP-1710 HBX 41108 LDN-91946 FT827 USP7-IN-6

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

C527 192718-06-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor C 527 DUBs Deubiquitinase C-527 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.