Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
2 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 563.00 | |
50 mg | In stock | $ 812.00 | |
100 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2, respectively. |
Targets&IC50 | Ub-MDM2:0.23 μM, USP7 catalytic domain:0.43 μM , full length USP7:0.75 μM , full length USP43:20.3 μM |
In vitro | GNE-6640 promotes endogenous MDM2 ubiquitination with Lys48 (K48)-linked polyubiquitin chains, which directs proteasomal degradation13. GNE-6640 targets cellular USP7, MDM2, and p53 signalling pathways. GNE-6640 decreases viability of 108 cell lines with IC50 ≤ 10 μM. Combining GNE-6640 with doxorubicin or cisplatin (DNA-damaging agents), which could activate the p53 response and enhance USP7 inhibitor efficacy. GNE-6640 could induce tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. |
Molecular Weight | 330.38 |
Formula | C20H18N4O |
CAS No. | 2009273-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (15.13 mM)
You can also refer to dose conversion for different animals. More
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GNE-6640 2009273-67-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Deubiquitinase DUBs inhibit Inhibitor GNE 6640 GNE6640 inhibitor