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IU1-47

Catalog No. T15604 CAS 670270-31-2

IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).

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IU1-47, CAS 670270-31-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 388.00
50 mg	In stock	$ 577.00
100 mg	In stock	$ 826.00
500 mg	In stock	$ 1,680.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 99.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
Targets&IC50	USP14:0.6 μM, IsoT/USP5:20 μM
In vitro	IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons.

Molecular Weight	330.85
Formula	C19H23ClN2O
CAS No.	670270-31-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (50.39 mM), Sonication is recommended.

References and Literature

1. Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Bioactive Compound Library Ubiquitination Compound Library Bioactive Compounds Library Max HIF-1 Signaling Pathway Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Cell Cycle Compound Library Covalent Inhibitor Library

Related Products

Related compounds with same targets

BAY 11-7082 P 22077 USP30 inhibitor 11 P22074 VLX1570 DUB-IN-3 DUB-IN-2 KSQ-4279

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IU1-47 670270-31-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibit IU1 47 Deubiquitinase IU-1-47 DUBs Inhibitor IU147 inhibitor

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