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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T41302 | Itaconate-alkyne | ITalk | Others |
Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its dire... | |||
T9849 | HQ461 | CDK , Molecular Glues | |
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. | |||
T22922 | Lenalidomide hemihydrate | TNF , Ligand for E3 Ligase , Molecular Glues | |
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. | |||
T0213 | Thalidomide | Thalomid,Sedoval | Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues |
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. | |||
T77915 | CCT367766 formic | PROTACs | |
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for degradation, effectively diminishing its protein expression at... | |||
T14908 | CCT367766 | PROTACs | |
CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN... | |||
T41174 | Thalidomide-Cyanine 5 | ||
Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET. | |||
T62235 | CDK-IN-9 | ||
CDK-IN-9 (compound 24) is a potent inhibitor of CDK. CDK-IN-9 is also a molecular gel that induces interaction between CDK12 and DDB1 and is able to act on CDK2/E (IC50: 4 nM). CDK-IN-9 can be used to dephosphorylate ret... | |||
T12560 | PROTAC BRD9 Degrader-1 | Epigenetic Reader Domain | |
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM. |