dca — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17731L	CL2A-SN-38 DCA 1279680-68-0(free base)		Others
	CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito...		Others
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
T13538	AlbA-DCA		ROS
	AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in the tumor micr...		ROS
T27551	Honokiol DCA	Honokiol Bis-Dichloroacetate
	Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo...
T60400	LDCA		Apoptosis , Dehydrogenase
	LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. ...		Apoptosis , Dehydrogenase
T23969	DCAI		Others
	DCAI is an inhibitor of nucleotide exchange and nucleotide release acting by binding to the pocket adjacent to the Ras-SOS interface.		Others
T81788	Mito-SilylDCA
	Mito-SilylDCA, a mitochondrial-targeted pyruvate dehydrogenase kinase (PDK1) inhibitor, possesses a thiamine pyrophosphate (TPP) moiety for PDK1 targeting within the mitochondrial network, several dichloroacetate (DCA) g...
T27127	DCAT Maleate	DCAT
	DCAT Maleate is an inhibitor of N-methyl transferases (NMT). DCAT Maleate methylate non-methylated pre-neurotoxins to prevent the formation of Parkinson's syndrome neurotoxins.
TN6015	N-Methyllindcarpine	2,11-Dihydroxy-1,10-dimethoxyaporphine
	N-Methyllindcarpine is a natural product of Lindera, Lauraceae. The catalog number is TN6015 and the CAS number is 14028-97-8. N-Methyllindcarpine can be used as a reference standard.
T72006	DCAI Hydrochloride
	DCAI hydrochloride is an inhibitor of nucleotide exchange and nucleotide release, by binding to the pocket adjacent to the Ras-SOS interface.
T82603	DCAF1 binder 2
	DCAF1 Binder 2, an E3 ligase ligand, is implicated in BRD9, kinase, and selective Bruton's tyrosine kinase (BTK) degradation.
T77965	DCAF1 binder 1
	DCAF1 Binder 1 selectively targets the CRL4 DCAF1 E3 ligase complex as a ligand, playing a role in targeted protein degradation (TPD) [1].
T36585	Isodeoxycholic Acid	isoDCA	Chloride channel , Antibacterial
	Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less...		Chloride channel , Antibacterial
T14778	BRD6989		IL Receptor , CDK , Interleukin
	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex...		IL Receptor , CDK , Interleukin
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ...
T27537	Hexafluoro
	Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo.