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BRD6989

Catalog No. T14778 CAS 642008-81-9

BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 or <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>19 complexes. BRD6989 selectively binds a complex of <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 with an IC50 of ~200 nM.

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BRD6989, CAS 642008-81-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 67.00
10 mg	In stock	$ 99.00
25 mg	In stock	$ 207.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 612.00

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Purity: 98.82%

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Storage & Solubility Information

Description	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
Targets&IC50	CDK8:200 nM (IC50), recombinant CDK8:0.5 μM (IC50), recombinant CDK19:>30 μM (IC50)
In vitro	Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production (EC50: ~1 μM). BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs. BRD6989 (5 μM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells. BRD6989 (5 μM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs.

Molecular Weight	264.33
Formula	C16H16N4
CAS No.	642008-81-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Cytokine Inhibitor Library Anti-Breast Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library Anti-Pancreatic Cancer Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library Pyroptosis Compound Library Inhibitor Library

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Keywords

BRD6989 642008-81-9 Cell Cycle/Checkpoint Immunology/Inflammation Interleukin CDK IL Receptor CDK8 BRD 6989 Inhibitor inhibit CDK19 IL-10 inflammatory Cyclin dependent kinase BRD-6989 BMDCs Interleukin Related cortistatin-A inhibitor

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