Powder: -20°C for 3 years
In solvent: -80°C for 2 years
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 or <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>19 complexes. BRD6989 selectively binds a complex of <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>8 with an IC50 of ~200 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 99.00 | |
25 mg | In stock | $ 207.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 612.00 |
Description | BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. |
Targets&IC50 | CDK8:200 nM (IC50), recombinant CDK8:0.5 μM (IC50), recombinant CDK19:>30 μM (IC50) |
In vitro | Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production (EC50: ~1 μM). BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs. BRD6989 (5 μM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells. BRD6989 (5 μM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs. |
Molecular Weight | 264.33 |
Formula | C16H16N4 |
CAS No. | 642008-81-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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BRD6989 642008-81-9 Cell Cycle/Checkpoint Immunology/Inflammation Interleukin CDK IL Receptor CDK8 BRD 6989 Inhibitor inhibit CDK19 IL-10 inflammatory Cyclin dependent kinase BRD-6989 BMDCs Interleukin Related cortistatin-A inhibitor