collagen-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60303	Collagen-IN-1
	Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Coll...
TN6975	Cirsiumaldehyde	5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation
	Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM)...		Platelet aggregation
T2386	Pirfenidone	S-7701,AMR-69,S-7701,AMR69	CCR , TGF-beta/Smad
	Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...		CCR , TGF-beta/Smad
T2769	3-Aminopropionitrile fumarate (2:1)	Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate	Others
	3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.		Others
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
T38294	4-Deoxypyridoxine hydrochloride		S1P Receptor
	4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib...		S1P Receptor
T80025	Bovine Type II Collagen	Collagen, Type II, Immunization Grade
	Type II collagen is a protein that demonstrates considerable effectiveness in alleviating pain and inflammation associated with collagen-induced arthritis in mice, with notable application in the treatment of osteoarthri...
T35725	4-hydroxy Valsartan
	4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when use...
T78030	GRGESP
	GRGESP is a collagen gel contraction inhibitor that impedes the spreading of human fibroblasts within collagen gels and significantly reduces gel contraction, thus serving as a valuable agent for research in connective t...
T36930	Palmitoyl Tetrapeptide-7 (acetate)
	Palmitoyl tetrapeptide-7 is a cosmeceutical peptide that stimulates type I collagen, fibronectin, and hyaluronic acid production in skin.1Formulations containing palmitoyl tetrapeptide-7 have been used in the treatment o...
TP2186	PalMitoyl Tripeptide-1		Others
	PalMitoyl Tripeptide-1 affects the synthesis of collagen, fibronectin and hyaluronic acid in human skin fibroblasts and can be used to prepare anti-aging cosmetics.		Others
T60557	TRAP-6-IN-1
	TRAP-6-IN-1 (Compound 8) is a dual inhibitor of collagen and TRAP-6 with IC 50 values of 17.12 μM and 11.88 μM, respectively. TRAP-6-IN-1 non-competitively inhibits agonist-induced platelet aggregation[1].
TP2186L1	PalMitoyl Tripeptide-1 hydrochloride	PalMitoyl Tripeptide-1 hydrochloride(147732-56-7 Free base)	Others
	PalMitoyl Tripeptide-1 hydrochloride (PalMitoyl Tripeptide-1 hydrochloride (147732-56-7 Free base)) has effects on the synthesis of collagen, fibronectin and hyaluronic acid in human skin fibroblasts, and can be used in ...		Others
T82780	Caprooyl-tetrapeptide-3 acetate
	Caprooyl-tetrapeptide-3 acetate, employed for diminishing fine lines and wrinkles, enhances collagen VII and laminin-5 expression in corticoid-induced skin aging models [1].
T61586	TGFβ-IN-2
	TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and ...
T73770	Galactosylhydroxylysine hydrochloride
	Galactosylhydroxylysine hydrochloride, a bone collagen component generated through hydroxylysine's post-translational glycosylation, is liberated during bone resorption. Its levels increase in cases of metabolic bone los...
T79983	Flaccidoside II		Apoptosis
	Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) cell lines and ameliorates collagen-in...		Apoptosis
T41079	MMP13-IN-2	MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over...