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Search Results for " adc "

20

Compounds

Cat No. Product Name Synonyms Targets
T20023 ADC-13 ADC 13 Others
ADC-13 is a bioactive chemical agent.
T29647 ADC-02390946
ADC-02390946 is a bioactive chemical.
T11249L Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ Topoisomerase
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
T74178 Glembatumumab vedotin CR011-vcMMAE,CR 011 ADC,CDX-011 Microtubule Associated
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).
T38889 Thailanstatin A
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T14348 Auristatin E Microtubule Associated
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...
T15175 DSP Crosslinker Others
DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1].
T15171 DSG Crosslinker Others
DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T14349 Auristatin F Microtubule Associated
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
T15058 DBCO-amine
DBCO-amine is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis[1].
T22334 FMOC-3VVD-OH Others
FMOC-3VVD-OH is an active chemical.
T15141 DM4 Ravtansine Others , Microtubule Associated
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
T15098 Deruxtecan Others
Deruxtecan is an ADC drug-linker conjugate consisting of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker for the synthesis of DS-8201 and U3-1402.
T1992 Mertansine DM1,Maytansinoid DM1 Microtubule Associated
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T4346 SPDB Others
SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
T3256 MMAF MonoMethyl auristatin F Others , Microtubule Associated
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T17389 AMAS Others
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.
T0968 Paclitaxel Taxol,NSC 125973 Apoptosis , Microtubule Associated , Autophagy
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
T8003 Methotrexate disodium Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
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