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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T20023 | ADC-13 | ADC 13 | Others |
ADC-13 is a bioactive chemical agent. | |||
T29647 | ADC-02390946 | ||
ADC-02390946 is a bioactive chemical. | |||
T11249L | Dxd | Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ | Topoisomerase |
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. | |||
T74178 | Glembatumumab vedotin | CR011-vcMMAE,CR 011 ADC,CDX-011 | Microtubule Associated |
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC). | |||
T38889 | Thailanstatin A | ||
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s... | |||
T14348 | Auristatin E | Microtubule Associated | |
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an... | |||
T15175 | DSP Crosslinker | Others | |
DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1]. | |||
T15171 | DSG Crosslinker | Others | |
DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis. | |||
T14349 | Auristatin F | Microtubule Associated | |
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates. | |||
T15058 | DBCO-amine | ||
DBCO-amine is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis[1]. | |||
T22334 | FMOC-3VVD-OH | Others | |
FMOC-3VVD-OH is an active chemical. | |||
T15141 | DM4 | Ravtansine | Others , Microtubule Associated |
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. | |||
T15098 | Deruxtecan | Others | |
Deruxtecan is an ADC drug-linker conjugate consisting of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker for the synthesis of DS-8201 and U3-1402. | |||
T1992 | Mertansine | DM1,Maytansinoid DM1 | Microtubule Associated |
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4... | |||
T11120 | Duocarmycin TM | DNA Alkylation , Antibiotic | |
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. | |||
T4346 | SPDB | Others | |
SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used. | |||
T3256 | MMAF | MonoMethyl auristatin F | Others , Microtubule Associated |
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin. | |||
T17389 | AMAS | Others | |
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules. | |||
T0968 | Paclitaxel | Taxol,NSC 125973 | Apoptosis , Microtubule Associated , Autophagy |
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy. | |||
T8003 | Methotrexate disodium | Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate | |
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |