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Neurotrophins

Neurotrophins are a family of proteins that induce the survival, development, and function of neurons. They belong to a class of growth factors, secreted proteins that can signal particular cells to survive, differentiate, or grow. Growth factors such as neurotrophins that promote the survival of neurons are known as neurotrophic factors. Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating programmed cell death-allowing the neurons to survive. Neurotrophins also induce differentiation of progenitor cells, to form neurons.

Although the vast majority of neurons in the mammalian brain are formed prenatally, parts of the adult brain (for example, the hippocampus) retain the ability to grow new neurons from neural stem cells, a process known as neurogenesis. Neurotrophins are chemicals that help to stimulate and control neurogenesis.

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Species
Canine (6)
Cynomolgus (10)
Ferret (2)
Human (56)
Mouse (25)
Rabbit (1)
Rat (10)
Rhesus (4)
Expression System
Baculovirus-Insect Cells (1)
CHO (3)
E. coli (32)
E.coli (2)
HEK293 (50)
Human Cells (13)
Yeast (1)
Tag
AVI (1)
C-6His (2)
C-His (1)
C-His-Avi (2)
His (25)
N-6His (3)
N-6His-Avi (1)
N-8His-Avi (3)
N-8His-Flag (1)
N-Avi (3)
N-His (7)
N-His-Avi (1)
N-hFc (7)
None (9)
Tag Free (28)
hFc (9)
Cat No. product name / Synonyms Species Expression System
TMPJ-00024 GMF beta/GMFB Protein, Human, Recombinant (His)
GMF beta/GMFB Protein, Human, Recombinant (His)
Human E. coli
Glia maturation factor beta (GMFB) contains a ADF-H domain,which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor...
TMPJ-00081 CNTF Protein, Human, Recombinant
CNTF Protein, Human, Recombinant
Human E. coli
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor ax...
TMPJ-00086 CT-1 Protein, Human, Recombinant (His)
CT-1 Protein, Human, Recombinant (His)
Human E. coli
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate ...
TMPJ-00100 Artemin Protein, Human, Recombinant
Artemin Protein, Human, Recombinant
Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
TMPJ-00124 TNF alpha Protein, Human, Recombinant (aa 77-233, His)
TNF alpha Protein, Human, Recombinant (aa 77-233, His)
Human E. coli
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressin...
TMPJ-00125 TNF alpha Protein, Human, Recombinant (aa 57-233, His)
TNF alpha Protein, Human, Recombinant (aa 57-233, His)
Human E. coli
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressin...
TMPJ-00134 Pro-BDNF Protein, Human, Recombinant
pro-BDNF Protein, Human, Recombinant
Human E. coli
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-con...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00259 TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00260 Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00622 Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
Cynomolgus Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant
TGF beta 1 Protein, Mouse/Rat, Recombinant
Mouse,Rat Human Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
TMPJ-00772 Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Mouse Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TMPJ-01414 GDF-15 Protein, Mouse, Recombinant (His & Flag)
GDF-15 Protein, Mouse, Recombinant (His & Flag)
Mouse Human Cells
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be ...
TMPK-00109 Artemin Protein, Human, Recombinant (hFc)
Artemin Protein, Human, Recombinant (hFc)
Human HEK293
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
TMPK-00119 TNF alpha Protein, Cynomolgus, Recombinant (His)
TNF alpha Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
TMPK-00120 TNF alpha Protein, Human, Recombinant (His & Avi)
TNF alpha Protein, Human, Recombinant (His & Avi)
Human HEK293
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
TMPK-00121 TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
GMF beta/GMFB Protein, Human, Recombinant (His)
TMPJ-00024
Glia maturation factor beta (GMFB) contains a ADF-H domain,which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor...
CNTF Protein, Human, Recombinant
TMPJ-00081
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor ax...
CT-1 Protein, Human, Recombinant (His)
TMPJ-00086
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate ...
Artemin Protein, Human, Recombinant
TMPJ-00100
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a varia...
TNF alpha Protein, Human, Recombinant (aa 77-233, His)
TMPJ-00124
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressin...
TNF alpha Protein, Human, Recombinant (aa 57-233, His)
TMPJ-00125
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressin...
pro-BDNF Protein, Human, Recombinant
TMPJ-00134
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-con...
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00250
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-te...
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00259
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00260
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00622
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular...
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPJ-00772
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell...
GDF-15 Protein, Mouse, Recombinant (His & Flag)
TMPJ-01414
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be ...
Artemin Protein, Human, Recombinant (hFc)
TMPK-00109
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor ...
TNF alpha Protein, Cynomolgus, Recombinant (His)
TMPK-00119
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
TNF alpha Protein, Human, Recombinant (His & Avi)
TMPK-00120
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00121
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that p...
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TargetMol